Abstract
Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.
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Acknowledgements
The authors wish to thank M.L.A.V. Heien for programming assistance, S. Ng-Evans and S.A. Wescott for technical assistance, and B.J. Aragona for review of this manuscript. This work was supported by US National Institute on Drug Abuse grants (DA018298 to M.F.R., DA10900 to R.M.W. and DA17318 to R.M.C.).
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M.F.R. and R.A.W. conducted the behavioral and electrochemical experiments and carried out data and graphical analyses. M.F.R. wrote the manuscript and R.A.W., R.M.W. and R.M.C. contributed to the writing of the manuscript.
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Supplementary Figures 1–6 and Supplementary Methods (PDF 655 kb)
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Roitman, M., Wheeler, R., Wightman, R. et al. Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli. Nat Neurosci 11, 1376–1377 (2008). https://doi.org/10.1038/nn.2219
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DOI: https://doi.org/10.1038/nn.2219
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