In a model of multiple sclerosis, tracing the fates of peripheral myeloid cells versus microglia fingers the peripheral cells in paralysis onset. Despite vigorous accumulation, peripheral cells disappear after disease resolution.
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References
Perry, V.H. Acta Neuropathol. 120, 277–286 (2010).
Ajami, B. et al. Nat Neurosci. 14, 1142–1149 (2011).
del Río-Hortega, P. & Penfield, W. Bull. Johns Hopkins Hosp. 41, 278–303 (1892).
Ginhoux, F. et al. Science 330, 841–845 (2010).
Alliot, F., Lecain, E., Grima, B. & Pessac, B. Proc. Natl. Acad. Sci. USA 88, 1541–1545 (1991).
Hawkes, C.A. & McLaurin, J. Proc. Natl. Acad. Sci. USA 106, 1261–1266 (2009).
Grathwohl, S.A. et al. Nat. Neurosci. 12, 1361–1363 (2009).
Ajami, B., Bennett, J.L., Krieger, C., Tetzlaff, W. & Rossi, F.M. Nat. Neurosci. 10, 1538–1543 (2007).
Saederup, N. et al. PLoS ONE 5, e13693 (2010).
Sica, A. et al. J. Exp. Med. 185, 969–974 (1997).
Bauer, J. et al. Glia 15, 437–446 (1995).
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Ransohoff, R. Microglia and monocytes: 'tis plain the twain meet in the brain. Nat Neurosci 14, 1098–1100 (2011). https://doi.org/10.1038/nn.2917
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DOI: https://doi.org/10.1038/nn.2917
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