A new paper shows that the transcription factor Dlx1, known to be involved in neuronal migration, is also necessary for interneuron survival. Mice lacking Dlx1 show subtype-specific loss of interneurons, a reduction in inhibitory currents and generalized seizures.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Integrated transcriptional analysis unveils the dynamics of cellular differentiation in the developing mouse hippocampus
Scientific Reports Open Access 22 December 2017
-
Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons
BMC Genomics Open Access 20 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wang, X.J., Tegner, J., Constantinidis, C. & Goldman-Rakic, P.S. Proc. Natl. Acad. Sci. USA 101, 1368–1373 (2004).
Sarkisian, M.R., Frenkel, M., Li, W., Oborski, J.A. & LoTurco, J.J. Cereb. Cortex 11, 734–743 (2001).
Powell, E.M. et al. J. Neurosci. 23, 622–631 (2003).
Pillai-Nair, N. et al. J. Neurosci. 25, 4659–4671 (2005).
Erbel-Sieler, C. et al. Proc. Natl. Acad. Sci. USA 101, 13648–13653 (2004).
Schwaller, B. et al. Mol. Cell. Neurosci. 25, 650–663 (2004).
Cobos, I. et al. Nat. Neurosci. 8, 1057–1066 (2005).
Yun, K. et al. Development 129, 5029–5040 (2002).
Sestan, N., Artavanis-Tsakonas, S. & Rakic, P. Science 286, 741–746 (1999).
Ding, M. et al. J. Mol. Neurosci. 8, 93–113 (1997).
Zhou, Q.P. et al. Nucleic Acids Res. 32, 884–892 (2004).
Anderson, S.A., Classey, J.D., Conde, F., Lund, J.S. & Lewis, D.A. Neuroscience 67, 7–22 (1995).
Fagiolini, M. et al. Science 303, 1681–1683 (2004).
Daviss, S.R. & Lewis, D.A. Psychiatry Res. 59, 81–96 (1995).
Spencer, K.M. et al. Proc. Natl. Acad. Sci. USA 101, 17288–17293 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wonders, C., Anderson, S. Beyond migration: Dlx1 regulates interneuron differentiation. Nat Neurosci 8, 979–981 (2005). https://doi.org/10.1038/nn0805-979
Issue Date:
DOI: https://doi.org/10.1038/nn0805-979