The vascular niche-derived factor PEDF enhances Notch signaling in adult neural stem cells via an unexpected mechanism involving nuclear export of a transcriptional repressor, to promote both proliferation and multipotentiality.
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Chojnacki, A., Weiss, S. Pigment epithelium-derived growth factor: modulating adult neural stem cell self-renewal. Nat Neurosci 12, 1481–1483 (2009). https://doi.org/10.1038/nn1209-1481
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DOI: https://doi.org/10.1038/nn1209-1481
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