Abstract
Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons: TrkA is expressed in neurons that sense temperature and noxious stimuli, and TrkC is expressed in proprioceptive neurons that sense body position. Neurotrophin signaling through these receptors is required for cell survival. To test whether neurotrophins have an instructive role in sensory specification, we expressed rat TrkC from the TrkA (also known as Ntrk1) locus in mice. The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes.
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Acknowledgements
We thank S. Arber, M. Barbacid, P. Mombaerts, P. Tsoulfas, B. Wold and J. Yoon for reagents; S. Kupriyanov and G. Story for assistance; and S. Halpain, N. Hong, U. Mueller and L. Stowers for critical reading of the manuscript. This work was mainly supported by a National Institute of Neurological Disorders and Stroke grant (5R01NS42822 to A.P.). Other support included: Basil O'Connor Starter Scholar Research Award to A.P., NIH P01-16033 to L.F.R., NIH R29NS37910 to D.E.W., and Spanish Ministry of Science and Technology grant (PM99-0118) to D.M.Z. A.P. is a Damon Runyon Scholar. L.F.R. is an investigator of the Howard Hughes Medical Institute.
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Moqrich, A., Earley, T., Watson, J. et al. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci 7, 812–818 (2004). https://doi.org/10.1038/nn1283
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DOI: https://doi.org/10.1038/nn1283
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