Optical tweezers have become one of the primary weapons in the arsenal of biophysicists, and have revolutionized the new field of single-molecule biophysics. Today's techniques allow high-resolution experiments on biological macromolecules that were mere pipe dreams only a decade ago.
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References
Ashkin, A., Dziedzic, J. M., Bjorkholm, J. E. & Chu, S. Opt. Lett. 11, 288–290 (1986).
Svoboda, K. & Block, S. M. Ann. Rev. Biophys. Biomol. Struct. 23, 247–285 (1994).
Neuman, K. C. & Block, S. M. Rev. Sci. Instrum. 75, 2787–2809 (2004).
Svoboda, K., Schmidt, C. F., Schnapp, B. J. & Block, S. M. Nature 365, 721–727 (1993).
Finer, J. T., Simmons, R. M. & Spudich, J. A. Nature 368, 113–119 (1994).
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R. & Block, S. M. Nature 438, 460–465 (2005).
Visscher, K. & Block, S. M. Meth. Enzymol. 298, 460–489 (1998).
Guydosh, N. R. & Block, S. M. Nature 461, 125–128 (2009).
Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I. Jr & Bustamante, C. Science 292, 733–737 (2001).
Woodside, M. T. et al. Science 314, 1001–1004 (2006).
Block, S. M., Asbury, C. L., Shaevitz, J. W. & Lang, M. J. Proc. Natl Acad. Sci. USA 100, 2351–2356 (2003).
Lang, M. J., Fordyce, P. M., Engh, A. M., Neuman, K. C. & Block, S. M. Nature Meth. 1, 133–139 (2004).
Comstock, M. J., Ha, T. & Chemla, Y. R. Nature Meth. 8, 335–340 (2011).
Carter, A. R. et al. Appl. Opt. 46, 421–427 (2007).
Moffitt, J. R., Chemla, Y. R., Izhaky, D. & Bustamante, C. Proc. Natl Acad. Sci. USA 103, 9006–9011 (2006).
Greenleaf, W. J., Woodside, M. T., Abbondanzieri, E. A. & Block, S. M. Phys. Rev. Lett. 95, 208102 (2005).
Kerssemakers, J. W. et al. Nature 442, 709–712 (2006).
Grier, D. G. Nature 424, 810–816 (2003).
La Porta, A. & Wang, M. D. Phys. Rev. Lett. 92, 190801 (2004).
Asbury, C. L., Fehr, A. N. & Block, S. M. Science 302, 2130–2134 (2003).
Larson, M. H., Landick, R. & Block, S. M. Mol. Cell 41, 249–262 (2011).
Galburt, E. A. et al. Nature 446, 820–823 (2007).
Smith, D. E. et al. Nature 413, 748–752 (2001).
Sakakibara, H., Kojima, H., Sakai, Y., Katayama, E. & Oiwa, K. Nature 400, 586–590 (1999).
Dumont, S. et al. Nature 439, 105–108 (2006).
Perkins, T. T., Li, H. W., Dalal, R. V., Gelles, J. & Block, S. M. Biophys. J. 86, 1640–1648 (2004).
Wen, J. D. et al. Nature 452, 598–603 (2008).
Wang, M. D., Yin, H., Landick, R., Gelles, J. & Block, S. M. Biophys. J. 72, 1335–1346 (1997).
Greenleaf, W. J., Frieda, K. L., Foster, D. A., Woodside, M. T. & Block, S. M. Science 319, 630–633 (2008).
Kellermayer, M. S., Smith, S. B., Granzier, H. L. & Bustamante, C. Science 276, 1112–1116 (1997).
Shank, E. A., Cecconi, C., Dill, J. W., Marqusee, S. & Bustamante, C. Nature 465, 637–640 (2010).
Hohng, S. et al. Science 318, 279–283 (2007).
van Mameren, J. et al. Nature 457, 745–748 (2009).
Brau, R. R., Tarsa, P. B., Ferrer, J. M., Lee, P. & Lang, M. J. Biophys. J. 91, 1069–1077 (2006).
Acknowledgements
S.M.B. acknowledges support from grant GM51453 from the National Institutes of Health.
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Fazal, F., Block, S. Optical tweezers study life under tension. Nature Photon 5, 318–321 (2011). https://doi.org/10.1038/nphoton.2011.100
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DOI: https://doi.org/10.1038/nphoton.2011.100
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