Abstract
Tumours are complex biological systems. No single type of molecular approach fully elucidates tumour behaviour, necessitating analysis at multiple levels encompassing genomics and proteomics. Integrated data sets are required to fully determine the contributions of genome alterations, host factors and environmental exposures to tumour growth and progression, as well as the consequences of interactions between malignant or premalignant cells and their microenvironment. The sheer amount and heterogeneous nature of data that need to be collected and integrated are daunting, but effort has already begun to address these obstacles.
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DATABASES
Cancer.gov
Entrez Gene
FURTHER INFORMATION
Biomolecular Interaction Database
Cancer Biomedical Informatics Grid
Database of Interacting Proteins
DBCAT, The Public Catalog of Databases
Director's Challenge initiative
Early Detection Research Network
European Bioinformatics Institute
Human Protein Reference Database
Kyoto Encyclopedia of Genes and Genomes
Mouse Models of Human Cancers Consortium
National Cancer Institute Gene Expression Data Portal
National Cancer Research Institute Cancer Informatics web site
National Center for Biotechnology Information
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Hanash, S. Integrated global profiling of cancer. Nat Rev Cancer 4, 638–644 (2004). https://doi.org/10.1038/nrc1414
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DOI: https://doi.org/10.1038/nrc1414
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