Uncertainty surrounds the benefit of β-blocker treatment in various clinical settings. The researchers in a new retrospective analysis of preoperative β-blocker use in CABG surgery now add to the debate, and suggest that these drugs might not improve perioperative outcomes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brinkman, W. et al. Preoperative beta-blocker use in coronary artery bypass grafting surgery. JAMA Intern. Med. http://dx.doi.org/10.1001/jamainternmed.2014.2356.
O'Gara, P. T. et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 127, 529–555 (2013).
Society of Thoracic Surgeons. Quality performance measures [online], (2014).
Fleisher, L. A. et al. 2009 ACCF/AHA focused update on perioperative beta blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Circulation 120, e169–e276 (2009).
Devereaux, P. J. et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial. Lancet 371, 1839–1847 (2008).
Bangalore, S. et al. Clinical outcomes with beta-blockers for myocardial infarction: a meta-analysis of randomized trials. Am. J. Med. http://dx.doi.org/10.1016/j.amjmed.2014.05.032.
Chen, Z. M. et al. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366, 1622–1632 (2005).
Ferguson, T. B. Jr, Coombs, L. P. & Peterson, E. D. Society of Thoracic Surgeons National Adult Cardiac Surgery Database. Preoperative beta-blocker use and mortality and morbidity following CABG surgery in North America. JAMA 287, 2221–2227 (2002).
Burgess, D. C., Kilborn, M. J. & Keech, A. C. Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis. Eur. Heart J. 27, 2846–2857 (2006).
Shahian, D. M. Preoperative beta-blockade in coronary artery bypass grafting surgery. JAMA Intern. Med. http://dx.doi.org/10.1001/jamainternmed.2014.155.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Vaishnava, P., Eagle, K. β-Blockers—still a trusted ally or time for retirement?. Nat Rev Cardiol 11, 502–503 (2014). https://doi.org/10.1038/nrcardio.2014.112
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrcardio.2014.112