The sodium–iodide symporter mediates iodide uptake, but its activity is reduced by the overexpression of pituitary tumour-transforming gene 1 protein-binding factor (PBF) in thyroid tumours. A recent study shows that inhibiting PBF phosphorylation enhances radioiodine uptake in thyroid cancer models.
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Acknowledgements
The authors' research is supported by the Department of Veterans Affairs Research Funds and an NIH grant (RO1 CA89364).
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Brent, G., Kogai, T. Novel target to enhance radioiodine uptake in thyroid cancer. Nat Rev Endocrinol 9, 508–509 (2013). https://doi.org/10.1038/nrendo.2013.132
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DOI: https://doi.org/10.1038/nrendo.2013.132