Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.
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Acknowledgements
F. Urano thanks the Washington University Wolfram Clinic, the Washington University Wolfram Study Group and participants in the Wolfram syndrome International Registry. F. Urano is supported by grants from the NIH (DK067493 and DK020579), Juvenile Diabetes Research Foundation (17-2013-512), American Diabetes Association (1-12-CT-61), Samuel E. Schechter Professorship, Ellie White Foundation for Rare Genetic Disorders, and the Jack and J. T. Snow Scientific Research Foundation.
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Urano, F. Targeting endoplasmic reticulum to combat juvenile diabetes. Nat Rev Endocrinol 10, 129–130 (2014). https://doi.org/10.1038/nrendo.2013.261
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DOI: https://doi.org/10.1038/nrendo.2013.261
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