Research published in Cell has shed light on the reorganization of circadian rhythm by nutrients. Mice fed a high-fat diet displayed extensive reprogramming of the hepatic clock with profound effects on key metabolic pathways. These changes involved repression of the Clock–Bmal1 network and PPARγ-regulated induction of a novel gene set.
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Acknowledgements
S.L. and R.M.E. are funded by a research grant from the Leona M. and Harry B. Helmsley Charitable Trust (#2012-PG-MED002) and an educational grant from Ipsen–Biomeasure.
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Liu, S., Evans, R. Tick, tock, a high-fat clock. Nat Rev Endocrinol 10, 191–192 (2014). https://doi.org/10.1038/nrendo.2014.23
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DOI: https://doi.org/10.1038/nrendo.2014.23