Exercise training is one of the key interventions for preventing and treating type 2 diabetes mellitus. Although the health-promoting effects of exercise are largely ascribed to improvements in skeletal muscle insulin sensitivity, new data published in Diabetes suggest 'exercise-trained' subcutaneous adipose tissue might also have an important role in enhancing glucose homeostasis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The Effect of a 12 Week Mixed-Modality Training Intervention on the Cardio-Metabolic Health of Rotational Shift Workers
Journal of Science in Sport and Exercise Open Access 24 November 2022
-
Fast synthesis of platinum nanopetals and nanospheres for highly-sensitive non-enzymatic detection of glucose and selective sensing of ions
Scientific Reports Open Access 30 October 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Egan, B. & Zierath, J. R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 17, 162–184 (2013).
Wallberg-Henriksson, H. & Holloszy, J. O. Contractile activity increases glucose uptake by muscle in severely diabetic rats. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 57, 1045–1049 (1984).
Hawley, J. A., Hargreaves, M., Joyner, M. J. & Zierath, J. R. Integrative biology of exercise. Cell 159, 738–749 (2014).
Craig, B. W., Hammons, G. T., Garthwaite, S. M., Jarett, L. & Holloszy, J. O. Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 51, 1500–1506 (1981).
Stanford, K. I. et al. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes http://dx.doi.org/10.2337/db14–0704.
Rosen, E. D. & Spiegelman, B. M. What we talk about when we talk about fat. Cell 156, 20–44 (2014).
Tran, T. T., Yamamoto, Y., Gesta, S. & Kahn, C. R. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 7, 410–420 (2008).
Enerback, S. The origins of brown adipose tissue. N. Engl. J. Med. 360, 2021–2023 (2009).
Kharitonenkov, A. et al. FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627–1635 (2005).
Craig, B. W., Thompson, K. & Holloszy, J. O. Effects of stopping training on size and response to insulin of fat cells in female rats. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 54, 571–575 (1983).
Acknowledgements
The authors acknowledge funding from The Swedish Research Council, European Research Council, Swedish Diabetes Association, Swedish Foundation for Strategic Research, Strategic Diabetes Research Program at Karolinska Institutet, Stockholm County Council and Novo Nordisk Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Wallberg-Henriksson, H., Zierath, J. Exercise remodels subcutaneous fat tissue and improves metabolism. Nat Rev Endocrinol 11, 198–200 (2015). https://doi.org/10.1038/nrendo.2015.24
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2015.24
This article is cited by
-
The Effect of a 12 Week Mixed-Modality Training Intervention on the Cardio-Metabolic Health of Rotational Shift Workers
Journal of Science in Sport and Exercise (2022)
-
Bone turnover response is linked to both acute and established metabolic changes in ultra-marathon runners
Endocrine (2017)
-
Implications of exercise-induced adipo-myokines in bone metabolism
Endocrine (2016)
-
Fast synthesis of platinum nanopetals and nanospheres for highly-sensitive non-enzymatic detection of glucose and selective sensing of ions
Scientific Reports (2015)