Abstract
The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins and rationale of these large-scale mouse mutagenesis programmes.
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Key mutation numbers and rates in ENU mutagenesis. (PDF 213 kb)
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FURTHER INFORMATION
AMMRA, Asian Mouse Mutagenesis and Resource Association
APF, Australian Phenomics Facility
Baylor College of Medicine ENU mouse mutagenesis
CARD, Center for Animal Resources and Development
CASIMIR, Coordination and Sustainability of International Mouse Informatics Resources
CMHD, Center for Modeling Human Disease
DBCLS, Database Center for Life Sciences
EMMA, European Mouse Mutant Archive
EMPReSS, European Mouse Phenotyping Resource of Standardized Screen (SOP database)
EuCOMM, European Conditional Mouse Mutagenesis
EUMODIC, The European Mouse Disease Clinic
Eumorphia, European Phenotyping Consortium 2002–2006
EURExpress II, gene expression atlas by RNA in situ
EuroPhenome, Europhenome Mouse Phenotyping Resource
Experimental Animal Division, RIKEN BioResource Center
FIMRe, Federation of International Mouse Resources
Helmholtz Zentrum Munchen German Research Center ENU mouse mutagenesis
IGTC, International Gene Trap Consortium
IMSR, International Mouse Strain Resource
INGENOtyping for ENU gene-driven mutagenesis
JAX Mice, The Jackson Laboratory
JAX Mouse Heart, Lung, Blood and Sleep Disorders Center
JAX Neuroscience Mutagenesis Facility
JMSR, Japan Mouse/Rat Strain Resource Database
McLaughlin Research Institue ENU mouse mutagenesis
Medical Research Council, archive for ENU gene-driven mutagenesis
Medical Research Council ENU mouse mutagenesis
MMRRC, Mutant Mouse Regional Resource Centers
NorCOMM, North American Conditional Mouse Mutagenesis
Northwestern University ENU mouse mutagenesis
Oak Ridge National Laboratory Mutant Mouse Database
PBmice, PiggyBac Mutagenesis Information Center
RIKEN Mutant Mouse Library, ENU-based gene-driven mutagenesis
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Gondo, Y. Trends in large-scale mouse mutagenesis: from genetics to functional genomics. Nat Rev Genet 9, 803–810 (2008). https://doi.org/10.1038/nrg2431
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DOI: https://doi.org/10.1038/nrg2431
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