Patients with elderly-onset IBD are more likely to have marked comorbidities and polypharmacy than those diagnosed at a younger age, which might affect therapeutic decision-making. Increased knowledge of this higher-risk group might guide patient management. Data from a large population-based study evaluating the clinical presentation and course of elderly-onset IBD are discussed.
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References
Census Data on Aging. US Department of Health and Human Services. Administration on Aging [online] (2011).
Molodecky N. A. et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142, 46–54 (2012).
Loftus, E. V. et al. Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gut 46, 336–343 (2000).
Loftus E. V. et al. Crohn's disease in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gastroenterology 114, 1161–1168 (1998).
Katz, S. & Pardi, D. S. Inflammatory bowel disease of the elderly: frequently asked questions (FAQs). Am. J. Gastroenterol. 106, 1889–1897 (2011).
Charpentier, C. et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut http://dx.doi.org/10.1136/gutjnl-2012-303864.
The burden of digestive diseases in the United States. NIDDK National Institute of Diabetes and Digestive and Kidney Diseases [online] (2008).
Ananthakrishnan, A. N., McGinley, E. L. & Binion, D. G. Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations. Inflamm. Bowel Dis. 15, 182–189 (2009).
Deuring, J. J. et al. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem. J. 441, 87–93 (2012).
Robertson, D. J. & Grimm, I. S. Inflammatory bowel disease in the elderly. Gastrointest. Clin. North Am. 30, 409–426 (2001).
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Ha, C., Katz, S. Elderly-onset IBD: a milder disease?. Nat Rev Gastroenterol Hepatol 10, 264–265 (2013). https://doi.org/10.1038/nrgastro.2013.56
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DOI: https://doi.org/10.1038/nrgastro.2013.56
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