A new genome-wide association study has identified four novel loci associated with eosinophilic oesophagitis. Two of these loci have been previously associated with atopic and autoimmune diseases (c11orf30 and STAT6); meanwhile, ANKRD27 regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14 encodes a calpain that is highly enriched in the oesophagus. The researchers suggest that these new loci might represent therapeutic targets for eosinophilic oesophagitis, namely oesophageal inflammation and remodelling.
References
Sleiman, P. M. et al. GWAS identifies four novel eosinophilic esophagitis loci. Nat. Commun. 10.1038/ncomms6593
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Novel loci associated with eosinophilic oesophagitis. Nat Rev Gastroenterol Hepatol 12, 5 (2015). https://doi.org/10.1038/nrgastro.2014.222
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DOI: https://doi.org/10.1038/nrgastro.2014.222