A novel extracorporeal liver assist device, called the University College London–Liver Dialysis Device, which removes dysfunctional albumin has been studied in a pig model of paracetamol-induced acute liver failure. If initiated 2 h after irreversible liver failure, device treatment resulted in a 67% reduced risk of death compared with a control device. A 54% reduction in overall severity of endotoxaemia and delays in the development of vasoplegia were also observed with the novel device.
References
Lee, K. C. L. et al. Extracorporeal liver-assist device to exchange albumin and remove endotoxin in acute liver failure: results of a pivotal pre-clinical study. J. Hepatol. 10.1016/j.jhep.2015.04.020
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Liver dialysis device demonstrates survival benefit in a pig model of paracetamol-induced acute liver failure. Nat Rev Gastroenterol Hepatol 12, 313 (2015). https://doi.org/10.1038/nrgastro.2015.84
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DOI: https://doi.org/10.1038/nrgastro.2015.84