Since the recognition of reflux oesophagitis as a disease entity, scientists and clinicians have commonly assumed that the first step in its pathogenesis was a loss of superficial epithelial cells, brought about by caustic acid injury. However, new data suggests that it is time to reconsider this concept.
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Smout, A., Bredenoord, A. A challenge to our view of reflux oesophagitis pathogenesis. Nat Rev Gastroenterol Hepatol 13, 504–505 (2016). https://doi.org/10.1038/nrgastro.2016.106
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DOI: https://doi.org/10.1038/nrgastro.2016.106