Abstract
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.
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Acknowledgements
The authors thank S. Wolff for her insightful ideas and comments. R.C.T. was funded by an Ellison Medical Foundation/American Federation for Aging Research (AFAR) Postdoctoral Fellowship. A.D. is cofounder of Proteostasis Therapeutics, Inc. and declares no financial interest related to this work. This work was supported by US NIH grant R01 AG042679.
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Taylor, R., Berendzen, K. & Dillin, A. Systemic stress signalling: understanding the cell non-autonomous control of proteostasis. Nat Rev Mol Cell Biol 15, 211–217 (2014). https://doi.org/10.1038/nrm3752
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DOI: https://doi.org/10.1038/nrm3752
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