Abstract
Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor–effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes.
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Beavo, J., Brunton, L. Cyclic nucleotide research — still expanding after half a century. Nat Rev Mol Cell Biol 3, 710–717 (2002). https://doi.org/10.1038/nrm911
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DOI: https://doi.org/10.1038/nrm911
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