Key Points
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A powerful approach to study self-consciousness has been to target brain mechanisms that process bodily signals (bodily self-consciousness).
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Bodily self-consciousness depends on three factors: self-identification with the body, self-location and the first-person perspective.
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Visuotactile and visuovestibular conflicts that induce changes in bodily self-consciousness have been tested using video, virtual reality and robotic devices.
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Experimental changes in illusory self-identification with a fake or virtual body are associated with changes in touch and pain perception, as well as physiological changes.
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Activity in the bilateral premotor cortex and posterior parietal cortex that is probably due to the activation of multisensory neurons integrating visual and somatosensory signals has been associated with self-identification.
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Neurological data in patients with heautoscopy reveal that damage to the left temporoparietal cortex leads to abnormal self-identification and self-location.
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Activity in the temporoparietal cortex and posterior parietal cortex that is probably due to the activation of multisensory neurons integrating vestibular, visual and tactile signals has been associated with self-location and the first-person perspective.
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Neurological data in patients with out-of-body experiences reveal that damage to the right temporoparietal cortex (posterior superior temporal gyrus) leads to abnormal self-location and first-person perspective.
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The interaction of these multisensory signals with other bodily signals, especially those related to interoceptive signals, and their respective importance for bodily self-consciousness and consciousness in general should be targeted by future research.
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Future neuro-rehabilitation procedures for amputees, stroke patients and patients with spinal cord injury are likely to benefit from the described automatized multisensory stimulations between augmented artificial bodies and residual own-body signals.
Abstract
Recent research has linked bodily self-consciousness to the processing and integration of multisensory bodily signals in temporoparietal, premotor, posterior parietal and extrastriate cortices. Studies in which subjects receive ambiguous multisensory information about the location and appearance of their own body have shown that these brain areas reflect the conscious experience of identifying with the body (self-identification (also known as body-ownership)), the experience of where 'I' am in space (self-location) and the experience of the position from where 'I' perceive the world (first-person perspective). Along with phenomena of altered states of self-consciousness in neurological patients and electrophysiological data from non-human primates, these findings may form the basis for a neurobiological model of bodily self-consciousness.
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References
Blanke, O. & Metzinger, T. Full-body illusions and minimal phenomenal selfhood. Trends Cogn. Sci. 13, 7–13 (2009).
Christoff, K., Cosmelli, D., Legrand, D. & Thompson, E. Specifying the self for cognitive neuroscience. Trends Cogn. Sci. 15, 104–112 (2011).
de Vignemont, F. Embodiment, ownership and disownership. Conscious. Cogn. 20, 82–93 (2011).
Jeannerod, M. The mechanism of self-recognition in humans. Behav. Brain Res. 142, 1–15 (2003).
Knoblich, G. Self-recognition: body and action. Trends Cogn. Sci. 6, 447–449 (2002).
Legrand, D. Pre-reflective self-as-subject from experiential and empirical perspectives. Conscious. Cogn. 16, 583–599 (2007).
Berlucchi, G. & Aglioti, S. The body in the brain: neural bases of corporeal awareness. Trends Neurosci. 20, 560–564 (1997). A comprehensive, classical review of deficits in body perception that are of relevance for bodily self-consciousness following brain damage in patients with neurological disorders.
Berlucchi, G. & Aglioti, S. M. The body in the brain revisited. Exp. Brain Res. 200, 25–35 (2010).
Critchley, M. The body-image in neurology. Lancet 255, 335–341 (1950).
Head, H. & Holmes, G. Sensory disturbances from cerebral lesions. Brain 34, 102–254 (1911).
Hécaen, H. & Ajuriaguerra, J. (eds) Meconnassiances et Hallucinations Corporelles: Integration et Desintegration de la Somatognosie 310–343 (Masson, 1952) (in French).
Lhermitte, J. L'image de Notre Corps 170–227 (L'Harmattan, 1998) (in French).
Schilder, P. The Image and Appearance of the Human Body (Georg Routledge and Sons, 1935).
Sollier, P. Les Phénomènes d'Autoscopie (Alcan, 1903) (in French).
Gerstmann, J. Problem of imperception of disease and of impaired body territories with organic lesions. Arch. Neurol. Psychiatry 48, 890–913 (1942).
Halligan, P. W., Marshall, J. C. & Wade, D. T. Unilateral somatoparaphrenia after right hemisphere stroke: a case description. Cortex 31, 173–182 (1995).
Fotopoulou, A. et al. Mirror-view reverses somatoparaphrenia: dissociation between first- and third-person perspectives on body ownership. Neuropsychologia 49, 3946–3955 (2011).
Vallar, G. & Ronchi, R. Somatoparaphrenia: a body delusion. A review of the neuropsychological literature. Exp. Brain Res. 192, 533–551 (2009).
Baier, B. & Karnath, H. O. Tight link between our sense of limb ownership and self-awareness of actions. Stroke 39, 486–488 (2008).
Botvinick, M. & Cohen, J. Rubber hands 'feel' touch that eyes see. Nature 391, 756 (1998).
Ehrsson, H. H., Spence, C. & Passingham, R. E. That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb. Science 305, 875–877 (2004).
Slater, M., Perez-Marcos, D., Ehrsson, H. H. & Sanchez-Vives, M. V. Towards a digital body: the virtual arm illusion. Front. Hum. Neurosci. 2, 6 (2008).
Tsakiris, M. & Haggard, P. The rubber hand illusion revisited: visuotactile integration and self-attribution. J. Exp. Psychol. Hum. Percept. Perform. 31, 80–91 (2005).
Kammers, M. P., de Vignemont, F., Verhagen, L. & Dijkerman, H. C. The rubber hand illusion in action. Neuropsychologia 47, 204–211 (2009).
Lloyd, D. M. Spatial limits on referred touch to an alien limb may reflect boundaries of visuo-tactile peripersonal space surrounding the hand. Brain Cogn. 64, 104–109 (2007).
Makin, T. R., Holmes, N. P. & Ehrsson, H. H. On the other hand: dummy hands and peripersonal space. Behav. Brain Res. 191, 1–10 (2008).
Tsakiris, M. My body in the brain: a neurocognitive model of body-ownership. Neuropsychologia 48, 703–712 (2010).
Rohde, M., Di Luca, M. & Ernst, M. O. The Rubber Hand Illusion: feeling of ownership and proprioceptive drift do not go hand in hand. PLoS ONE 6, e21659 (2011).
Ehrsson, H. H., Holmes, N. P. & Passingham, R. E. Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas. J. Neurosci. 25, 10564–10573 (2005).
Kammers, M. P. et al. Is this hand for real? Attenuation of the rubber hand illusion by transcranial magnetic stimulation over the inferior parietal lobule. J. Cogn. Neurosci. 21, 1311–1320 (2009).
Kanayama, N., Sato, A. & Ohira, H. Crossmodal effect with rubber hand illusion and gamma-band activity. Psychophysiology 44, 392–402 (2007).
Kanayama, N., Sato, A. & Ohira, H. The role of gamma band oscillations and synchrony on rubber hand illusion and crossmodal integration. Brain Cogn. 69, 19–29 (2009).
Tsakiris, M., Hesse, M. D., Boy, C., Haggard, P. & Fink, G. R. Neural signatures of body ownership: a sensory network for bodily self-consciousness. Cereb. Cortex 17, 2235–2244 (2007).
Ehrsson, H. H., Wiech, K., Weiskopf, N., Dolan, R. J. & Passingham, R. E. Threatening a rubber hand that you feel is yours elicits a cortical anxiety response. Proc. Natl Acad. Sci. USA 104, 9828–9833 (2007).
Lloyd, D., Morrison, I. & Roberts, N. Role for human posterior parietal cortex in visual processing of aversive objects in peripersonal space. J. Neurophysiol. 95, 205–214 (2006).
Zeller, D., Gross, C., Bartsch, A., Johansen-Berg, H. & Classen, J. Ventral premotor cortex may be required for dynamic changes in the feeling of limb ownership: a lesion study. J. Neurosci. 31, 4852–4857 (2011).
Bremmer, F. et al. Polymodal motion processing in posterior parietal and premotor cortex: a human fMRI study strongly implies equivalencies between humans and monkeys. Neuron 29, 287–296 (2001).
Fogassi, L. et al. Coding of peripersonal space in inferior premotor cortex (area F4). J. Neurophysiol. 76, 141–157 (1996).
Gentile, G., Petkova, V. I. & Ehrsson, H. H. Integration of visual and tactile signals from the hand in the human brain: an FMRI study. J. Neurophysiol. 105, 910–922 (2011).
Graziano, M. S. & Gandhi, S. Location of the polysensory zone in the precentral gyrus of anesthetized monkeys. Exp. Brain Res. 135, 259–266 (2000).
Graziano, M. S., Hu, X. T. & Gross, C. G. Visuospatial properties of ventral premotor cortex. J. Neurophysiol. 77, 2268–2292 (1997).
Iriki, A., Tanaka, M. & Iwamura, Y. Coding of modified body schema during tool use by macaque postcentral neurones. Neuroreport 7, 2325–2330 (1996).
Maravita, A. & Iriki, A. Tools for the body (schema). Trends Cogn. Sci. 8, 79–86 (2004). An important review on multisensory integration of the upper extremity, in particular the integration of visual, tactile and proprioceptive signals in the parietal cortex of human and non-human primates.
Petkova, V. I. et al. From part- to whole-body ownership in the multisensory brain. Curr. Biol. 21, 1118–1122 (2011). An important study on the brain mechanisms of self-identification using fMRI and virtual reality.
Farne, A., Iriki, A. & Ladavas, E. Shaping multisensory action–space with tools: evidence from patients with cross-modal extinction. Neuropsychologia 43, 238–248 (2005).
Holmes, N. P., Calvert, G. A. & Spence, C. Tool use changes multisensory interactions in seconds: evidence from the crossmodal congruency task. Exp. Brain Res. 183, 465–476 (2007).
Maravita, A., Spence, C., Sergent, C. & Driver, J. Seeing your own touched hands in a mirror modulates cross-modal interactions. Psychol. Sci. 13, 350–355 (2002).
Graziano, M. S., Cooke, D. F. & Taylor, C. S. Coding the location of the arm by sight. Science 290, 1782–1786 (2000). Important research in macaque monkeys on the neurophysiology of area 5 neurons and the integration of visual, proprioceptive and tactile cues. These findings are of relevance for self-attribution of an individual's hand.
Dieguez, S., Mercier, M. R., Newby, N. & Blanke, O. Feeling numbness for someone else's finger. Curr. Biol. 19, R1108–R1109 (2009).
Tastevin, J. En partant de lexpérience d'Aristote: les déplacements artificiels des parties du corps ne sont pas suivis par le sentiment de ces parties ni pas les sensations qu'on peut y produire. Encephale 1, 140–158 (1937) (in French).
Brugger, P., Regard, M. & Landis, T. Unilaterally felt presences: the neuropsychiatry of one's invisible Doppelgänger. Neuropsychiatry Neuropsychol. Behav. Neurol. 9, 114–122 (1996).
Heydrich, L., Dieguez, S., Grunwald, T., Seeck, M. & Blanke, O. Illusory own body perceptions: case reports and relevance for bodily self-consciousness. Conscious. Cogn. 19, 702–710 (2010).
Sforza, A., Bufalari, I., Haggard, P. & Aglioti, S. M. My face in yours: visuo-tactile facial stimulation influences sense of identity. Soc. Neurosci. 5, 148–162 (2010).
Tsakiris, M. Looking for myself: current multisensory input alters self-face recognition. PLoS ONE 3, e4040 (2008).
Bolognini, N., Ladavas, E. & Farne, A. Spatial perspective and coordinate systems in autoscopy: a case report of a “fantome de profil” in occipital brain damage. J. Cogn. Neurosci. 23, 1741–1751 (2011).
Devinsky, O., Feldmann, E., Burrowes, K. & Bromfield, E. Autoscopic phenomena with seizures. Arch. Neurol. 46, 1080–1088 (1989).
Grusser, O. J. & Landis, T. in Visual Agnosia and Other Disturbances of Visual Perception and Cognition (eds Grusser, O. J. & Landis, T.) 297–303 (Macmillan, 1991).
Ehrsson, H. H. The experimental induction of out-of-body experiences. Science 317, 1048 (2007).
Ionta, S. et al. Multisensory mechanisms in temporo-parietal cortex support self-location and first-person perspective. Neuron 70, 363–374 (2011). An important study on the brain mechanisms of self-identification, self-location and the first-person perspective using fMRI with neuroscience robotics.
Lenggenhager, B., Tadi, T., Metzinger, T. & Blanke, O. Video ergo sum: manipulating bodily self-consciousness. Science 317, 1096–1099 (2007).
Lenggenhager, B., Mouthon, M. & Blanke, O. Spatial aspects of bodily self-consciousness. Conscious. Cogn. 18, 110–117 (2009).
Altschuler, E. L. & Ramachandran, V. S. A simple method to stand outside oneself. Perception 36, 632–634 (2007).
Mizumoto, M. & Ishikawa, M. Immunity to error through misidentification and the bodily illusion experiment J. Conscious. Stud. 12, 3–19 (2005).
Ramachandran, V. S., Rogers-Ramachandran, D. & Cobb, S. Touching the phantom limb. Nature 377, 489–490 (1995).
Stratton, G. M. The spatial harmony of touch and sight. Mind 8 492–505 (1899).
von Helmholtz, H. Helmholtz's Treatise on Physiological Optics (Dover Publication, 1962).
Spence, C., Pavani, F. & Driver, J. Spatial constraints on visual-tactile cross-modal distractor congruency effects. Cogn. Affect Behav. Neurosci. 4, 148–169 (2004).
Aspell, J. E., Lenggenhager, B. & Blanke, O. Keeping in touch with one's self: multisensory mechanisms of self-consciousness. PLoS ONE 4, e6488 (2009).
Igarashi, Y., Kimura, Y., Spence, C. & Ichihara, S. The selective effect of the image of a hand on visuotactile interactions as assessed by performance on the crossmodal congruency task. Exp. Brain Res. 184, 31–38 (2008).
Pavani, F. & Castiello, U. Binding personal and extrapersonal space through body shadows. Nature Neurosci. 7, 14–16 (2004).
Pavani, F., Spence, C. & Driver, J. Visual capture of touch: out-of-the-body experiences with rubber gloves. Psychol. Sci. 11, 353–359 (2000).
Shore, D. I., Barnes, M. E. & Spence, C. Temporal aspects of the visuotactile congruency effect. Neurosci. Lett. 392, 96–100 (2006).
Aspell, J. E., Lavanchy, T., Lenggenhager, B. & Blanke, O. Seeing the body modulates audiotactile integration. Eur. J. Neurosci. 31, 1868–1873 (2010).
Zopf, R., Savage, G. & Williams, M. A. Crossmodal congruency measures of lateral distance effects on the rubber hand illusion. Neuropsychologia 48, 713–725 (2010).
Petkova, V. I. & Ehrsson, H. H. If I were you: perceptual illusion of body swapping. PLoS ONE 3, e3832 (2008).
Hansel, A., Lenggenhager, B., von Kanel, R., Curatolo, M. & Blanke, O. Seeing and identifying with a virtual body decreases pain perception. Eur. J. Pain 15, 874–879 (2011).
Lenggenhager, B., Halje, P. & Blanke, O. Alpha band oscillations correlate with illusory self-location induced by virtual reality. Eur. J. Neurosci. 33, 1935–1943 (2011).
Pineda, J. A. The functional significance of mu rhythms: translating “seeing” and “hearing” into “doing”. Brain Res. Brain Res. Rev. 50, 57–68 (2005).
Oakes, T. R. et al. Functional coupling of simultaneous electrical and metabolic activity in the human brain. Hum. Brain Mapp. 21, 257–270 (2004).
Gastaut, H. Etude électrocorticographique de la réactivité des rhythms rolandiques. Rev. Neurol. (Paris) 87, 176–182 (1952) (in French).
Pfurtscheller, G. & Neuper, C. Motor imagery activates primary sensorimotor area in humans. Neurosci. Lett. 239, 65–68 (1997).
Ulloa, E. R. & Pineda, J. A. Recognition of point-light biological motion: mu rhythms and mirror neuron activity. Behav. Brain Res. 183, 188–194 (2007).
Pfurtscheller, G. Central beta rhythm during sensorimotor activities in man. Electroencephalogr. Clin. Neurophysiol. 51, 253–264 (1981).
Cheyne, D. et al. Neuromagnetic imaging of cortical oscillations accompanying tactile stimulation. Brain Res. Cogn. Brain Res. 17, 599–611 (2003).
Astafiev, S. V., Stanley, C. M., Shulman, G. L. & Corbetta, M. Extrastriate body area in human occipital cortex responds to the performance of motor actions. Nature Neurosci. 7, 542–548 (2004).
Downing, P. E., Jiang, Y., Shuman, M. & Kanwisher, N. A cortical area selective for visual processing of the human body. Science 293, 2470–2473 (2001).
Grossman, E. D. & Blake, R. Brain areas active during visual perception of biological motion. Neuron 35, 1167–1175 (2002).
Urgesi, C., Candidi, M., Ionta, S. & Aglioti, S. M. Representation of body identity and body actions in extrastriate body area and ventral premotor cortex. Nature Neurosci. 10, 30–31 (2007).
Duhamel, J. R., Colby, C. L. & Goldberg, M. E. in Brain and Space (ed. Paillard, J.) 223–236 (Oxford Univ. Press, 1991).
Duhamel, J. R., Colby, C. L. & Goldberg, M. E. Ventral intraparietal area of the macaque: congruent visual and somatic response properties. J. Neurophysiol. 79, 126–136 (1998). Pioneering work on the neurophysiology of VIP neurons and the integration of visual and tactile cues that are likely to be of relevance for self-identification.
Armel, K. C. & Ramachandran, V. S. Projecting sensations to external objects: evidence from skin conductance response. Proc. Biol. Sci. 270, 1499–1506 (2003).
Taoka, M., Toda, T., Iriki, A., Tanaka, M. & Iwamura, Y. Bilateral receptive field neurons in the hindlimb region of the postcentral somatosensory cortex in awake macaque monkeys. Exp. Brain Res. 134, 139–146 (2000).
Taoka, M., Toda, T. & Iwamura, Y. Representation of the midline trunk, bilateral arms, and shoulders in the monkey postcentral somatosensory cortex. Exp. Brain Res. 123, 315–322 (1998).
Sakata, H., Taira, M., Murata, A. & Mine, S. Neural mechanisms of visual guidance of hand action in the parietal cortex of the monkey. Cereb. Cortex 5, 429–438 (1995).
Kitada, R., Johnsrude, I. S., Kochiyama, T. & Lederman, S. J. Functional specialization and convergence in the occipito-temporal cortex supporting haptic and visual identification of human faces and body parts: an fMRI study. J. Cogn. Neurosci. 21, 2027–2045 (2009).
Cardini, F. et al. Viewing one's own face being touched modulates tactile perception: an fMRI study. J. Cogn. Neurosci. 23, 503–513 (2011).
Brugger, P. Reflective mirrors: perspective-taking in autoscopic phenomena. Cogn. Neuropsychiatry 7, 179–194 (2002).
Blanke, O. & Mohr, C. Out-of-body experience, heautoscopy, and autoscopic hallucination of neurological origin: implications for neurocognitive mechanisms of corporeal awareness and self-consciousness. Brain Res. Brain Res. Rev. 50, 184–199 (2005). A useful review about the neurological findings in a large number of patients suffering from autoscopic phenomena that are associated with abnormal bodily self-consciousness.
Lukianowicz, N. Autoscopic phenomena. AMA Arch. Neurol. Psychiatry 80, 199–220 (1958).
Blanke, O., Landis, T., Spinelli, L. & Seeck, M. Out-of-body experience and autoscopy of neurological origin. Brain 127, 243–258 (2004).
Brugger, P., Agosti, R., Regard, M., Wieser, H. G. & Landis, T. Heautoscopy, epilepsy, and suicide. J. Neurol. Neurosurg. Psychiatry 57, 838–839 (1994).
Pearson, J. & Dewhurst, K. Two cases of heautoscopic phenomena following organic lesions. Encephale 43, 166–172 (1954).
Lunn, V. Autoscopic phenomena. Acta Psych Scand. 46, 118–125 (1970).
Avillac, M., Deneve, S., Olivier, E., Pouget, A. & Duhamel, J. R. Reference frames for representing visual and tactile locations in parietal cortex. Nature Neurosci. 8, 941–949 (2005).
De Ridder, D., Van Laere, K., Dupont, P., Menovsky, T. & Van de Heyning, P. Visualizing out-of-body experience in the brain. N. Engl. J. Med. 357, 1829–1833 (2007).
Claparede, E. D. Note sur la localisation du moi. Arch. Psychol. 19, 172–182 (1924) (in French).
Hoffmann, F. R. Über die Sehrichtungen. Graefe's Arch. Clin. Exp. Opthalmol. 116, 135–142 (1926) (in German).
Bertossa, F., Besa, M., Ferrari, R. & Ferri, F. Point zero: a phenomenological inquiry into the seat of consciousness. Percept. Mot. Skills 107, 323–335 (2008).
Limanowski, J. & Hecht, H. Where do we stand on locating the self? Psychology 2, 312–317 (2011).
Roelofs, C. O. Considerations on the visual egocenter. Acta Pschol. 16, 226–234 (1959).
Harris, C. S. Perceptual adaptation to inverted, reversed, and displaced vision. Psychol. Rev. 72, 419–444 (1965).
Held, R. & Freedman, S. J. Plasticity in human sensorimotor control. Science 142, 455–462 (1963).
Kohler, I. Uber Aufbau und Wandlungen der Wahrnehmungswelt. Östereichische Akademie der Wissenschaften. Philosophisch historische Klasse 227, 1–118 (1951) (in German).
Pisella, L., Rode, G., Farne, A., Tilikete, C. & Rossetti, Y. Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders. Curr. Opin. Neurol. 19, 534–542 (2006).
Welch, R. B. Research on adaptation to rearranged vision: 1966–1974. Perception 3, 367–392 (1974).
Brugger, P., Regard, M. & Landis, T. Illusory reduplication of one's own body: phenomenology and classification of autoscopic phenomena. Cogn. Neuropsychiatry 2, 19–38 (1997).
Dennett, D. C. Consciousness Explained (Penguin Books, 1991).
Nagel, T. The View from Nowhere (Oxford Univ. Press, 1986).
Shoemaker, S. The First-person Perspective and Other Essays (Cambridge Univ. Press, 1996).
Blanke, O., Ortigue, S., Landis, T. & Seeck, M. Stimulating illusory own-body perceptions. Nature 419, 269–270 (2002).
Penfield, W. & Jaspers, H. Epilepsy and the Functional Anatomy of the Human Brain (Little Brown & Co, 1954).
Tong, F. Out-of-body experiences: from Penfield to present. Trends Cogn. Sci. 7, 104–106 (2003).
Brandt, C., Brechtelsbauer, D., Bien, C. G. & Reiners, K. [Out-of-body experience as possible seizure symptom in a patient with a right parietal lesion]. Nervenarzt 76, 1259–1262 (2005) (in German).
Maillard, L., Vignal, J. P., Anxionnat, R. & TaillandierVespignani, L. Semiologic value of ictal autoscopy. Epilepsia 45, 391–394 (2004).
Arzy, S., Thut, G., Mohr, C., Michel, C. M. & Blanke, O. Neural basis of embodiment: distinct contributions of temporoparietal junction and extrastriate body area. J. Neurosci. 26, 8074–8081 (2006).
Petkova, V. I., Khoshnevis, M. & Ehrsson, H. H. The perspective matters! Multisensory integration in ego-centric reference frames determines full-body ownership. Front. Psychol. 2, 35 (2011).
Slater, M., Spanlang, B., Sanchez-Vives, M. V. & Blanke, O. First person experience of body transfer in virtual reality. PLoS ONE 5, e10564 (2010).
David, N. et al. Neural representations of self versus other: visual-spatial perspective taking and agency in a virtual ball-tossing game. J. Cogn. Neurosci. 18, 898–910 (2006).
Vogeley, K. & Fink, G. R. Neural correlates of the first-person-perspective. Trends Cogn. Sci. 7, 38–42 (2003).
Vogeley, K. et al. Neural correlates of first-person perspective as one constituent of human self-consciousness. J. Cogn. Neurosci. 16, 817–827 (2004).
Corradi-Dell'acqua, C. et al. Effects of shifting perspective of the self: an fMRI study. Neuroimage 40, 1902–1911 (2008).
Zacks, J. M. & Michelon, P. Transformations of visuospatial images. Behav. Cogn. Neurosci. Rev. 4, 96–118 (2005).
Burgess, N., Maguire, E. A., Spiers, H. J. & O'Keefe, J. A temporoparietal and prefrontal network for retrieving the spatial context of lifelike events. Neuroimage 14, 439–453 (2001).
Lambrey, S. et al. Distinct visual perspective-taking strategies involve the left and right medial temporal lobe structures differently. Brain 131, 523–534 (2008).
Golomer, E., Cremieux, J., Dupui, P., Isableu, B. & Ohlmann, T. Visual contribution to self-induced body sway frequencies and visual perception of male professional dancers. Neurosci. Lett. 267, 189–192 (1999).
Isableu, B., Ohlmann, T., Cremieux, J. & Amblard, B. Selection of spatial frame of reference and postural control variability. Exp. Brain Res. 114, 584–589 (1997).
Lopez, C., Lacour, M., Magnan, J. & Borel, L. Visual field dependence-independence before and after unilateral vestibular loss. Neuroreport 17, 797–803 (2006).
Young, L. R., Oman, C. M., Watt, D. G., Money, K. E. & Lichtenberg, B. K. Spatial orientation in weightlessness and readaptation to earth's gravity. Science 225, 205–208 (1984).
Green, C. E. Out-of-Body Experiences (Hamish Hamilton, 1968).
Gurovskiy, N. N., Bryanov, I. I. & Yegorov, A. D. Changes in the vestibular function during space flight. Acta Astronaut. 2, 207–216 (1975).
Kornilova, L. N. Orientation illusions in spaceflight. J. Vestib. Res. 7, 429–439 (1997).
Lackner, J. R. Spatial orientation in weightless environments. Perception 21, 803–812 (1992).
Graybiel, A. & Kellogg, R. S. Inversion illusion in parabolic flight: its probable dependence on otolith function. Aerosp. Med. 38, 1099–1103 (1967).
Aubert, H. Eine scheinbare bedeutende Drehung von Objecten bei Neigung des Kopfes nach rechts oder links. Virchows Archiv. 20, 381–393 (1861) (in German).
Jenkin, H. L., Dyde, R. T., Jenkin, M. R., Howard, I. P. & Harris, L. R. Relative role of visual and non-visual cues in determining the direction of “up”: experiments in the York tilted room facility. J. Vestib. Res. 13, 287–293 (2003).
Lopez, C., Bachofner, C., Mercier, M. & Blanke, O. Gravity and observer's body orientation influence the visual perception of human body postures. J. Vis. 9, 11–14 (2009).
Mittelstaedt, H. The role of the otoliths in perception of the orientation of self and world to the vertical. Zool. Jahrb. Abt Physiol. 95, 418–425 (1991).
Lopez, C., Halje, P. & Blanke, O. Body ownership and embodiment: vestibular and multisensory mechanisms. Neurophysiol. Clin. 38, 149–161 (2008).
Solms, M., Kaplan-Solms, K., Saling, M. & Miller, P. Inverted vision after frontal lobe disease. Cortex 24, 499–509 (1988).
Tiliket, C., Ventre-Dominey, J., Vighetto, A. & Grochowicki, M. Room tilt illusion. A central otolith dysfunction. Arch. Neurol. 53, 1259–1264 (1996).
Chan, A. W., Peelen, M. V. & Downing, P. E. The effect of viewpoint on body representation in the extrastriate body area. Neuroreport 15, 2407–2410 (2004).
Saxe, R., Jamal, N. & Powell, L. My body or yours? The effect of visual perspective on cortical body representations. Cereb. Cortex 16, 178–182 (2006).
Grusser, O. J., Pause, M. & Schreiter, U. Vestibular neurones in the parieto-insular cortex of monkeys (Macaca fascicularis): visual and neck receptor responses. J. Physiol. 430, 559–583 (1990).
Grusser, O. J., Pause, M. & Schreiter, U. Localization and responses of neurones in the parieto-insular vestibular cortex of awake monkeys (Macaca fascicularis). J. Physiol. 430, 537–557 (1990). Pioneering work on the neurophysiology of PIVC neurons and the integration of visual, vestibular and somatosensory cues that are likely to be of relevance for self-location and the first-person perspective.
Robinson, C. J. & Burton, H. Somatotopographic organization in the second somatosensory area of M. fascicularis. J. Comp. Neurol. 192, 43–67 (1980).
Schneider, R. J., Friedman, D. P. & Mishkin, M. A modality-specific somatosensory area within the insula of the rhesus monkey. Brain Res. 621, 116–120 (1993).
Guldin, W. O., Akbarian, S. & Grusser, O. J. Cortico-cortical connections and cytoarchitectonics of the primate vestibular cortex: a study in squirrel monkeys (Saimiri sciureus). J. Comp. Neurol. 326, 375–401 (1992).
Guldin, W. O. & Grusser, O. J. Is there a vestibular cortex? Trends Neurosci. 21, 254–259 (1998).
Lopez, C. & Blanke, O. The thalamocortical vestibular system in animals and humans. Brain Res. Rev. 67, 119–146 (2011). A comprehensive review about the vestibular cortex and the processing of vestibular, visual and somatosensory signals including neurophysiological, neuroanatomical and neuroimaging data in animals and humans.
Duffy, C. J. MST neurons respond to optic flow and translational movement. J. Neurophysiol. 80, 1816–1827 (1998).
Duffy, C. J. & Wurtz, R. H. Sensitivity of MST neurons to optic flow stimuli. I. A continuum of response selectivity to large-field stimuli. J. Neurophysiol. 65, 1329–1345 (1991).
Tanaka, K. & Saito, H. Analysis of motion of the visual field by direction, expansion/contraction, and rotation cells clustered in the dorsal part of the medial superior temporal area of the macaque monkey. J. Neurophysiol. 62, 626–641 (1989).
Schlack, A., Hoffmann, K. P. & Bremmer, F. Interaction of linear vestibular and visual stimulation in the macaque ventral intraparietal area (VIP). Eur. J. Neurosci. 16, 1877–1886 (2002).
Bremmer, F., Klam, F., Duhamel, J. R., Ben Hamed, S. & Graf, W. Visual-vestibular interactive responses in the macaque ventral intraparietal area (VIP). Eur. J. Neurosci. 16, 1569–1586 (2002). Important work on the neurophysiology of VIP neurons and the integration of visual, vestibular and somatosensory cues that are likely to be of relevance for self-identification, self-location and the first-person perspective.
Bremmer, F., Kubischik, M., Pekel, M., Lappe, M. & Hoffmann, K. P. Linear vestibular self-motion signals in monkey medial superior temporal area. Ann. NY Acad. Sci. 871, 272–281 (1999).
Fetsch, C. R., Wang, S., Gu, Y., Deangelis, G. C. & Angelaki, D. E. Spatial reference frames of visual, vestibular, and multimodal heading signals in the dorsal subdivision of the medial superior temporal area. J. Neurosci. 27, 700–712 (2007).
Gu, Y., Angelaki, D. E. & Deangelis, G. C. Neural correlates of multisensory cue integration in macaque MSTd. Nature Neurosci. 11, 1201–1210 (2008).
Gu, Y., DeAngelis, G. C. & Angelaki, D. E. A functional link between area MSTd and heading perception based on vestibular signals. Nature Neurosci. 10, 1038–1047 (2007).
MacNeilage, P. R., Banks, M. S., Berger, D. R. & Bulthoff, H. H. A. Bayesian model of the disambiguation of gravitoinertial force by visual cues. Exp. Brain Res. 179, 263–290 (2007).
Metzinger, T. Being No One (MIT Press, 2003).
Craig, A. D. How do you feel — now? The anterior insula and human awareness. Nature Rev. Neurosci. 10, 59–70 (2009).
Damasio, A. & Meyer, D. E. in The Neurology of Consciousness (eds Laureys, S. & Tononi, G.) 3–14 (Elsevier, 2009).
Damasio, A. R. The Feeling of What Happens: Body and Emotion in the Making of Consciousness (Harcourt Brace, 1999).
Pacherie, E. The phenomenology of action: a conceptual framework. Cognition 107, 179–217 (2008).
Tsakiris, M., Tajadura-Jimenez, A. & Costantini, M. Just a heartbeat away from one's body: interoceptive sensitivity predicts malleability of body-representations. Proc. Biol. Sci. 278, 2470–2476 (2011).
Fox, M. D. & Raichle, M. E. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Rev. Neurosci. 8, 700–711 (2007).
Greicius, M. D., Supekar, K., Menon, V. & Dougherty, R. F. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb. Cortex 19, 72–78 (2009).
Golland, Y. et al. Extrinsic and intrinsic systems in the posterior cortex of the human brain revealed during natural sensory stimulation. Cereb. Cortex 17, 766–777 (2007).
Crick, F. & Koch, C. Some reflections on visual awareness. Cold Spring Harb. Symp. Quant. Biol. 55, 953–962 (1990).
Weiskrantz, L. Consciousness Lost and Found (Oxford Univ. Press, 1997).
Dehaene, S. & Changeux, J. P. Experimental and theoretical approaches to conscious processing. Neuron 70, 200–227 (2011).
Edelman, G. Bright Air, Brilliant Fire (Basic Books, 1992).
Esslen, M., Metzler, S., Pascual-Marqui, R. & Jancke, L. Pre-reflective and reflective self-reference: a spatiotemporal EEG analysis. Neuroimage 42, 437–449 (2008).
Gillihan, S. J. & Farah, M. J. Is self special? A critical review of evidence from experimental psychology and cognitive neuroscience. Psychol. Bull. 131, 76–97 (2005).
Heatherton, T. F. et al. Medial prefrontal activity differentiates self from close others. Soc. Cogn. Affect Neurosci. 1, 18–25 (2006).
Legrand, D. & Ruby, P. What is self-specific? Theoretical investigation and critical review of neuroimaging results. Psychol. Rev. 116, 252–282 (2009).
Macrae, C. N., Moran, J. M., Heatherton, T. F., Banfield, J. F. & Kelley, W. M. Medial prefrontal activity predicts memory for self. Cereb. Cortex 14, 647–654 (2004).
Northoff, G. et al. Self-referential processing in our brain — a meta-analysis of imaging studies on the self. Neuroimage 31, 440–457 (2006).
Perrin, F. et al. Neural mechanisms involved in the detection of our first name: a combined ERPs and PET study. Neuropsychologia 43, 12–19 (2005).
Platek, S. M. et al. Neural substrates for functionally discriminating self-face from personally familiar faces. Hum. Brain Mapp. 27, 91–98 (2006).
Gazzaniga, M. S., LeDoux, J. E. & Wilson, D. H. Language, praxis, and the right hemisphere: clues to some mechanisms of consciousness. Neurology 27, 1144–1147 (1977).
Arzy, S., Arzouan, Y., Adi-Japha, E., Solomon, S. & Blanke, O. The 'intrinsic' system in the human cortex and self-projection: a data driven analysis. Neuroreport 21, 569–574 (2010).
Arzy, S., Bick, A. & Blanke, O. Mental time in amnesia: evidence from bilateral medial temporal damage before and after recovery. Cogn. Neuropsychol. 26, 503–510 (2009).
Saxe, R., Moran, J. M., Scholz, J. & Gabrieli, J. Overlapping and non-overlapping brain regions for theory of mind and self reflection in individual subjects. Soc. Cogn. Affect Neurosci. 1, 229–234 (2006).
Moore, J. W., Lagnado, D., Deal, D. C. & Haggard, P. Feelings of control: contingency determines experience of action. Cognition 110, 279–283 (2009).
Herbelin, B. Virtual Reality Exposure Therapy for Social Phobia. Thesis, Ecole Polytechnique Federale de Lausanne (2005).
Klinger, E. et al. Virtual reality therapy versus cognitive behavior therapy for social phobia: a preliminary controlled study. Cyberpsychol. Behav. 8, 76–88 (2005).
Moseley, G. L., Gallace, A. & Spence, C. Space-based, but not arm-based, shift in tactile processing in complex regional pain syndrome and its relationship to cooling of the affected limb. Brain 132, 3142–3151 (2009).
Barnsley, N. et al. The rubber hand illusion increases histamine reactivity in the real arm. Curr. Biol. 21, R945–R946 (2011).
Ehrsson, H. H. et al. Upper limb amputees can be induced to experience a rubber hand as their own. Brain 131, 3443–3452 (2008).
Marasco, P. D., Kim, K., Colgate, J. E., Peshkin, M. A. & Kuiken, T. A. Robotic touch shifts perception of embodiment to a prosthesis in targeted reinnervation amputees. Brain 134, 747–758 (2011).
Blanke, O. & Aspell, J. E. Brain technologies raise unprecedented ethical challenges. Nature 458, 703 (2009).
Hochberg, L. R. et al. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442, 164–171 (2006).
Nicolelis, M. Beyond Boundaries. The Neuroscience of Connecting Brains with Machines and How It will Change our Lives (Times Books, 2011).
Perez-Marcos, D., Slater, M. & Sanchez-Vives, M. V. Inducing a virtual hand ownership illusion through a brain-computer interface. Neuroreport 20, 589–594 (2009).
Creem, S. H. et al. An fMRI study of imagined self-rotation. Cogn. Affect Behav. Neurosci. 1, 239–249 (2001).
Wraga, M., Shephard, J. M., Church, J. A., Inati, S. & Kosslyn, S. M. Imagined rotations of self versus objects: an fMRI study. Neuropsychologia 43, 1351–1361 (2005).
Aichhorn, M., Perner, J., Kronbichler, M., Staffen, W. & Ladurner, G. Do visual perspective tasks need theory of mind? Neuroimage 30, 1059–1068 (2006).
Zacks, J., Rypma, B., Gabrieli, J. D., Tversky, B. & Glover, G. H. Imagined transformations of bodies: an fMRI investigation. Neuropsychologia 37, 1029–1040 (1999).
Schwabe, L., Lenggenhager, B. & Blanke, O. The timing of temporoparietal and frontal activations during mental own body transformations from different visuospatial perspectives. Hum. Brain Mapp. 30, 1801–1812 (2009).
Amorim, M. A. & Stucchi, N. Viewer- and object-centered mental explorations of an imagined environment are not equivalent. Brain Res. Cogn. Brain Res. 5, 229–239 (1997).
Wang, R. F. & Simons, D. J. Active and passive scene recognition across views. Cognition 70, 191–210 (1999).
Clement, G., Moore, S. T., Raphan, T. & Cohen, B. Perception of tilt (somatogravic illusion) in response to sustained linear acceleration during space flight. Exp. Brain Res. 138, 410–418 (2001).
Iriki, A., Tanaka, M., Obayashi, S. & Iwamura, Y. Self-images in the video monitor coded by monkey intraparietal neurons. Neurosci. Res. 40, 163–173 (2001).
Acknowledgements
The author thanks C. Pfeiffer for his valuable help on the manuscript. The author is supported by grants from the Swiss National Science Foundation (SINERGIA CRSII1-125135), the European Science Foundation (FP7 project VERE) and the Bertarelli Foundation.
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Glossary
- Body ownership
-
The feeling that the physical body and its parts, such as its hands and feet, belong to 'me' and are 'my' body.
- Trimodal neurons
-
Neurons that respond to signals from three perceptual domains. One type of trimodal neuron responds to visual, tactile and proprioceptive signals; another type of trimodal neuron responds to visual, tactile and vestibular signals.
- Proprioceptive signals
-
Sensory signals about limb and body position.
- Autoscopic phenomena
-
A group of illusory own-body perceptions during which subjects report seeing a second own-body in extracorporeal space. They include autoscopic hallucination, heautoscopy and out-of-body experiences.
- Heautoscopy
-
The phenomenon in which the subject experiences seeing a second own-body in extracorporeal space. Subjects often report strong self-identification with the second own-body and heautoscopy is often associated with the sensation of bi-location (that is, the sensation of being at two places at the same time).
- Ego-centre
-
A single point from which human observers believe they are viewing a spatial scene. Ego-centres have been investigated for visual, auditory or kinaesthetic stimuli.
- Prism adaptation
-
The phenomenon that subjects who wear prism glasses that introduce spatial mismatches between the seen position of visual cues and their actual spatial coordinates learn to correctly perceive and reach for visual targets.
- Out-of-body experience
-
(OBE). The phenomenon in which the subject experiences seeing a second own-body from an elevated and distanced extracorporeal position. Subjects often report disembodiment (that is, a sensation of separation from their physical body) and sensations of flying and lightness.
- Virtual mirrors
-
Part of an immersive virtual reality scenario that includes a region where the image and movements of the immersed user will be simulated as if reflected from a physical mirror.
- Egocentric
-
An umbrella term for maps and/or patterns of modulation that can be defined in relation to some point on the observer (for example, head- or eye-centred maps).
- Allocentric
-
An umbrella term for maps and/or patterns of modulation that are defined in relation to an object external to the observer.
- Microgravity environment
-
Environments in which no gravity exists for short periods (parabolic flight) or prolonged periods (orbital flight).
- Vestibular neurons
-
Neurons responding to activation of receptors in the vestibular labyrinth (semicircular canals and otolith organs).
- Otoliths
-
Organs in the vestibular labyrinth of the inner ear that are sensitive to linear acceleration and gravity.
- Translational signals
-
Otolithic vestibular signals that cause linear acceleration.
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Blanke, O. Multisensory brain mechanisms of bodily self-consciousness. Nat Rev Neurosci 13, 556–571 (2012). https://doi.org/10.1038/nrn3292
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DOI: https://doi.org/10.1038/nrn3292
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