Renal fibrosis and anaemia are hallmarks of progressive chronic kidney disease (CKD). New evidence demonstrates that these conditions are intimately connected, as injury triggers the phenotypic transition of renal erythropoietin-producing cells into fibrogenic myofibroblasts. Strategies to reverse such a transition may hold promise to alleviate both anaemia and fibrosis in CKD.
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Xiao, L., Liu, Y. Fibrosis and anaemia in CKD—two beasts, one ancestor. Nat Rev Nephrol 9, 563–565 (2013). https://doi.org/10.1038/nrneph.2013.179
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DOI: https://doi.org/10.1038/nrneph.2013.179