Two types of parietal podocyte were previously described in the Bowman capsule: one characterized by coexpression of podocyte and parietal epithelial cell markers, the other characterized by expression of podocyte markers only. New research demonstrates that these populations represent podocyte progenitors and ectopic podocytes—distinct cell types with different clinical implications.
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References
Eknoyan, G. Sir William Bowman: his contributions to physiology and nephrology. Kidney Int. 50, 2120–2128 (1996).
Marcus, P. B. Podocytic “metaplasia” of parietal Bowman's capsular epithelium. Arch. Pathol. Lab. Med. 101, 664 (1977).
Bariety, J., Mandet, C., Hill, G. S. & Bruneval, P. Parietal podocytes in normal human glomeruli. J. Am. Soc. Nephrol. 17, 2770–2780 (2006).
Romagnani, P., Lasagni, L. & Remuzzi, G. Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat. Rev. Nephrol. 9, 137–146 (2013).
Appel, D. et al. Recruitment of podocytes from glomerular parietal epithelial cells. J. Am. Soc. Nephrol. 20, 333–343 (2009).
Schulte, K. et al. Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013040376.
Naveiras, O. et al. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460, 259–263 (2009).
Wharram, B. L. et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J. Am. Soc. Nephrol. 16, 2941–2952 (2005).
Peired, A. et al. Proteinuria impairs podocyte regeneration by sequestering retinoic acid. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2012090950.
Remuzzi, G., Benigni, A. & Remuzzi, A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J. Clin. Invest. 116, 288–296 (2006).
Acknowledgements
P. Romagnani's work is supported by the European Community's Seventh Framework Programme (FP7/2012-2016), grant number 305436.
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Lasagni, L., Romagnani, P. Podocyte progenitors and ectopic podocytes. Nat Rev Nephrol 9, 715–716 (2013). https://doi.org/10.1038/nrneph.2013.247
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DOI: https://doi.org/10.1038/nrneph.2013.247