Polycystic Kidney disease (PKD) is caused by mutations in genes that affect cilia structure and composition. Impaired mechanosensation through primary cilia has been proposed as a pathogenic mechanism in PKD; however, a new study challenges this hypothesis by showing an absence of mechanically induced Ca2+ increases in primary cilia.
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References
Torres, V. E., Harris, P. C. & Pirson, Y. Autosomal dominant polycystic kidney disease. Lancet 369, 1287–1301 (2007).
Singla, V. & Reiter, J. F. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 313, 629–633 (2006).
Nauli, S. M. et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33, 129–137 (2003).
Praetorius, H. A. & Spring, K. R. Bending the MDCK cell primary cilium increases intracellular calcium. J. Membr. Biol. 184, 71–79 (2001).
Boehlke, C. et al. Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat. Cell Biol. 12, 1115–1122 (2010).
Praetorius, H. A. The primary cilium as sensor of fluid flow: new building blocks to the model. A review in the theme: cell signaling: proteins, pathways and mechanisms. Am. J. Physiol. Cell Physiol. 308, C198–C208 (2015).
Delling, M. et al. Primary cilia are not calcium-responsive mechanosensors. Nature 531, 656–660 (2016).
Delling, M., DeCaen, P. G., Doerner, J. F., Febvay, S. & Clapham, D. E. Primary cilia are specialized calcium signalling organelles. Nature 504, 311–314 (2013).
Su, S. et al. Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nat. Methods 10, 1105–1107 (2013).
Kottgen, M. et al. TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182, 437–447 (2008).
Acknowledgements
M.K. is supported by the German Research Foundation (CRU 201, CRC 1140, CRC/TRR 152).
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Hofherr, A., Köttgen, M. Cilia and mechanosensation revisited. Nat Rev Nephrol 12, 318–319 (2016). https://doi.org/10.1038/nrneph.2016.61
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DOI: https://doi.org/10.1038/nrneph.2016.61
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