Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the evidence from clinicopathological studies on neurodegenerative changes is at odds with these observations. A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity.
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References
Sonnen, J. A. et al. Different patterns of cerebral injury in dementia with or without diabetes. Arch. Neurol. 66, 315–322 (2009).
Xu, W. L., von Strauss, E., Qiu, C. X., Winblad, B. & Fratiglioni, L. Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study. Diabetologia doi: 10.1007/s00125-009-1323-x.
Alafuzoff, I., Aho, L., Helisalmi, S., Mannermaa, A. & Soininen, H. β-Amyloid deposition in brains of subjects with diabetes. Neuropathol. Appl. Neurobiol. 35, 60–68 (2009).
Kalaria, R. N. et al. Towards defining the neuropathological substrates of vascular dementia. J. Neurol. Sci. 226, 75–80 (2004).
van Harten, B., de Leeuw, F. E., Weinstein, H. C., Scheltens, P. & Biessels, G. J. Brain imaging in patients with diabetes: a systematic review. Diabetes Care 29, 2539–2548 (2006).
Beeri, M. S. et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 71, 750–757 (2008).
Arvanitakis, Z. et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 67, 1960–1965 (2006).
Peila, R., Rodriguez, B. L. & Launer, L. J. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 51, 1256–1262 (2002).
Wilcock, D. M. & Colton, C. A. Anti-Aβ immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. J. Alzheimers Dis. 15, 555–569 (2008).
Nelson, P. T. et al. Human cerebral neuropathology of type 2 diabetes mellitus. Biochim. Biophys. Acta 1792, 454–469 (2008).
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Kalaria, R. Diabetes, microvascular pathology and Alzheimer disease. Nat Rev Neurol 5, 305–306 (2009). https://doi.org/10.1038/nrneurol.2009.72
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DOI: https://doi.org/10.1038/nrneurol.2009.72