The understanding and treatment of medulloblastoma, the most common childhood malignant brain tumour, is rapidly evolving. Three complementary deep-sequencing studies that were recently published in Nature add to our knowledge of this disease, further refine risk stratification, and identify potential druggable targets.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pan-cancer driver copy number alterations identified by joint expression/CNA data analysis
Scientific Reports Open Access 14 October 2020
-
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Acta Neuropathologica Open Access 22 November 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Packer, R. J. et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J. Clin. Oncol. 24, 4202–4208 (2006).
Ris, M. D., Packer, R., Goldwein, J., Jones-Wallace, D. & Boyett, J. M. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J. Clin. Oncol. 19, 3470–3476 (2001).
Armstrong, G. T. et al. Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro Oncol. 12, 1173–1186 (2010).
Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123, 465–472 (2012).
Kool, M. K. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 123, 473–484 (2012).
Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106–110 (2012).
Parsons, D. W. et al. The genetic landscape of the childhood cancer medulloblastoma. Science 331, 435–439 (2011).
Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488, 100–105 (2012).
Northcott, P. A. et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488, 49–56 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Packer, R., Hoffman, E. Understanding the molecular complexity of medulloblastoma. Nat Rev Neurol 8, 539–540 (2012). https://doi.org/10.1038/nrneurol.2012.197
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2012.197
This article is cited by
-
Pan-cancer driver copy number alterations identified by joint expression/CNA data analysis
Scientific Reports (2020)
-
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Acta Neuropathologica (2014)