Impaired γ-aminobutyric acid (GABA) signalling is known to have a role in epilepsy, highlighting this process as a potential therapeutic target. Hunt et al. grafted GABAergic progenitors into the hippocampus of epileptic adult mice. The cells migrated throughout the hippocampal subfield and differentiated into functional inhibitory interneurons. Moreover, cell transplantation reduced seizure frequency by 92% and restored behavioural deficits in domains such as spatial learning.
ORIGINAL RESEARCH PAPER
Hunt, R. F. et al. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat. Neurosci. doi:10.1038/nn.3392
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Transplantation of interneuron progenitors shows promise in mouse model of epilepsy. Nat Rev Neurol 9, 358 (2013). https://doi.org/10.1038/nrneurol.2013.114
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DOI: https://doi.org/10.1038/nrneurol.2013.114