Genome-wide association studies have provided important insights into the genetic underpinnings of Alzheimer disease (AD), but the relevance of the identified variants to AD pathogenesis is often unclear. A new study uses a powerful quantitative trait approach to identify genetic variants that are associated with biologically meaningful parameters in AD.
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Apostolova, L. A quantitative trait approach to GWAS pays dividends. Nat Rev Neurol 13, 321–322 (2017). https://doi.org/10.1038/nrneurol.2017.61
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DOI: https://doi.org/10.1038/nrneurol.2017.61
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