A variant in the TNFSF13B gene that encodes B-cell-activating factor has been found to increase the risk of multiple sclerosis and systemic lupus erythematosus in the Sardinian population. The findings underscore, and offer new insight into, the role of B cells in these autoimmune disorders, and have implications for personalized therapy.
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References
Krumbholz, M., Derfuss, T., Hohlfeld, R. & Meinl, E. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat. Rev. Neurol. 8, 613–623 (2012).
Bird, A. K., Meednu, N. & Anolik, J. H. New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome. Curr. Opin. Rheumatol. 27, 461–467 (2015).
Townsend, M. J., Monroe, J. G. & Chan, A. C. B-cell targeted therapies in human autoimmune diseases: an updated perspective. Immunol. Rev. 237, 264–283 (2010).
Piazza, F. et al. Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis. J. Neuroimmunol. 220, 104–107 (2010).
Steri, M. et al. Overexpression of the cytokine BAFF and autoimmunity risk. N. Engl. J. Med. 376, 1615–1626 (2017).
Cocco, E. et al. Epidemiology of multiple sclerosis in south-western Sardinia. Mult. Scler. 17, 1282–1289 (2011).
Liu, X. Q. et al. Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. Eur. J. Immunol. 42, 3291–3301 (2012).
Krumbholz, M. et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med. 201, 195–200 (2005).
Serafini, B. et al. Epstein–Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J. Neuropathol. Exp. Neurol. 69, 677–693 (2010).
Magliozzi, R. et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130, 1089–1104 (2007).
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Comabella, M. B cells and variant BAFF in autoimmune disease. Nat Rev Neurol 13, 453–454 (2017). https://doi.org/10.1038/nrneurol.2017.87
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DOI: https://doi.org/10.1038/nrneurol.2017.87