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Genetics

Susceptibility loci in a molecular subtype of prostate cancer

Nature Reviews Urology volume 6, pages 357–358 (2009)Cite this article

Genetic linkage has recently been reported between several genomic loci and a subtype of prostate cancer that contains a fusion between the genes TMPRSS2 and ERG. These data suggest an analytical approach that might improve future studies of the genetic cause of prostate and other cancers.

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References

  1. Easton, D. F., Schaid, D. J., Whittemore, A. S. & Isaacs, W. J. Where are the prostate cancer genes? A summary of eight genome wide searches. Prostate 57, 261–269 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Witte, J. S. Prostate cancer genomics: towards a new understanding. Nat. Rev. Genet. 10, 77–82 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644–648 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Narod, S. A., Seth, A. & Nam, R. Fusion in the ETS gene family and prostate cancer. Br. J. Cancer 99, 847–851 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hofer, M. D. et al. Genome-wide linkage analysis of TMPRSS2–ERG fusion in familial prostate cancer. Cancer Res. 69, 640–646 (2009).

    Article  CAS  PubMed  Google Scholar 

  6. Maier, C., Herkommer, K., Hoegel, J., Vogel, W. & Paiss, T. A genomewide linkage analysis for prostate cancer susceptibility genes in families from Germany. Eur. J. Hum. Genet. 13, 352–360 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Xu, J. et al. Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat. Genet. 20, 175–179 (1998).

    Article  CAS  PubMed  Google Scholar 

  8. Carter, B. S. et al. Hereditary prostate cancer: epidemiologic and clinical features. J. Urol. 150, 797–802 (1993).

    Article  CAS  PubMed  Google Scholar 

  9. Hall, J. M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684–1689 (1990).

    Article  CAS  PubMed  Google Scholar 

  10. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11, 241–247 (1995).

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. Memorial Sloan–Kettering Cancer Center, Cancer Biology and Genetics, New York, NY, USA

    Robert J. Klein

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  1. Robert J. Klein
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Correspondence to Robert J. Klein.

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The author declares no competing financial interests.

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Klein, R. Susceptibility loci in a molecular subtype of prostate cancer. Nat Rev Urol 6, 357–358 (2009). https://doi.org/10.1038/nrurol.2009.108

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  • DOI: https://doi.org/10.1038/nrurol.2009.108

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