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Degrading liaisons: Siah structure revealed

Nature Structural Biology volume 9, pages 8–10 (2002)Cite this article

The structure of the substrate-binding domain of Siah provides insight into how this protein interacts with a diverse set of substrate proteins.

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Figure 1: Pathways involving Siah/Sina-family proteins.
Figure 2: The SBD of Siah is structurally similar to the TRAF domain of TRAF family proteins.
Figure 3: Surface representation of the Siah dimer and potential protein–protein interaction regions.

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Acknowledgements

We thank C. Li for modeling and graphics, S. Matsuzawa for helpful discussions, and A. Sawyer for manuscript preparation.

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  1. the Burnham Institute, 10901 N.Torrey Pines Rd, La Jolla, 92037, California, USA

    John C. Reed & Kathryn R. Ely

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  1. John C. Reed
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Correspondence to John C. Reed or Kathryn R. Ely.

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Reed, J., Ely, K. Degrading liaisons: Siah structure revealed. Nat Struct Mol Biol 9, 8–10 (2002). https://doi.org/10.1038/nsb0102-8

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