A large kinetic barrier prevents spontaneous disassembly of SNARE complexes, complicating thermodynamic measurements and resulting in hysteresis. Nonetheless, this kinetic barrier is probably crucial for SNARE function.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jahn, R. & Südhof, T.C. Annu. Rev. Biochem. 68, 863–911 (1999).
Söllner, T. et al. Nature 362, 318–324 (1993).
Skehel, J.J. & Wiley, D.C. Cell 95, 871–874 (1998).
Weber, T. et al. Cell 92, 759–772 (1998).
Waters, M.G. & Hughson, F.M. Traffic 1, 588–597 (2000).
Sutton, R.B., Fasshauer, D., Jahn, R. & Brunger, A.T. Nature 395, 347–353 (1998).
Weimbs, T. et al. Proc. Natl. Acad. Sci. U.S.A. 94, 3046–3051 (1997).
Hayashi, T. et al. EMBO J. 13, 5051–5061 (1994).
Hanson, P.I., Roth, R., Morisaki, H., Jahn, R. & Heuser, J.E. Cell 90, 523–535 (1997).
May, A.P., Whiteheart, S.W. & Weis, W.I. J. Biol. Chem. 276, 21991–21994. (2001).
Fasshauer, D., Antonin, W., Subramaniam, V. & Jahn, R. Nature Struct. Biol. 9, 144–151 (2002).
Feynman, R.P., Leighton, R.B. & Sands, M. The Feynman Lectures on Physics, Vol. II (Addison-Wesley Publishing Co., Reading, Massachusetts; 1964).
Brokate, M. & Sprekels, J. Hysteresis and Phase Transitions (Springer-Verlag, New York; 1996).
Steinhardt, J. & Zaiser, E.M. Adv. Protein Chem. 10, 151–226 (1955).
Knight, C.A., DeVries, A.L. & Oolman, L.D. Nature 308, 295–296 (1984).
Kellermayer, M.S., Smith, S.B., Granzier, H.L. & Bustamante, C. Science 276, 1112–1116 (1997).
Liphardt, J., Onoa, B., Smith, S.B., Tinoco, I.J. & Bustamante, C. Science 292, 733–737 (2001).
Adkins, C.J. Equilibrium Thermodynamics (Cambridge University Press, Cambridge; 1997).
Wendt, H., Berger, C., Baici, A., Thomas, R.M. & Bosshard, H.R. Biochemistry 34, 4097–4107 (1995).
Ibarra-Molero, B., Makhatadze, G.I. & Matthews, C.R. Biochemistry 40, 719–731 (2001).
Sosnick, T.R., Jackson, S., Wilk, R.R., Englander, S.W. & DeGrado, W.F. Proteins 24, 427–432 (1996).
Carr, C.M. & Novick, P.J. Nature 404, 347–349 (2000).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Barrick, D., Hughson, F. Irreversible assembly of membrane fusion machines. Nat Struct Mol Biol 9, 78–80 (2002). https://doi.org/10.1038/nsb0202-78
Issue Date:
DOI: https://doi.org/10.1038/nsb0202-78