RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 Å resolution crystal structure of the human RhoA–GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.
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Wei, Y., Zhang, Y., Derewenda, U. et al. Crystal structure of RhoA–GDP and its functional implications. Nat Struct Mol Biol 4, 699–703 (1997). https://doi.org/10.1038/nsb0997-699
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DOI: https://doi.org/10.1038/nsb0997-699
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