The crystal structure of Plasmodium falciparum lactate dehydrogenase reveals a surprising shift in the position of the NADH cofactor that explains the unusual biochemical properties of this enzyme. There is also a distinctive surface cleft adjacent to the NADH binding pocket that forms an attractive target for inhibitor design.
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Dunn, C., Banfield, M., Barker, J. et al. The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design. Nat Struct Mol Biol 3, 912–915 (1996). https://doi.org/10.1038/nsb1196-912
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DOI: https://doi.org/10.1038/nsb1196-912
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