Two complementary papers demonstrate that the homologous type II transmembrane proteins LAP1 and LULL1 adopt nucleotide-free AAA+ ATPase folds and donate arginine fingers to complete the active sites of Torsin AAA+ ATPases. Activated Torsin complexes appear to function in nuclear and endoplasmic reticulum membrane-remodeling processes, including a nuclear vesiculation pathway that carries large cellular and viral cargoes from the nucleus into the cytoplasm.
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ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function
Nature Communications Open Access 14 October 2015
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McCullough, J., Sundquist, W. Putting a finger in the ring. Nat Struct Mol Biol 21, 1025–1027 (2014). https://doi.org/10.1038/nsmb.2928
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DOI: https://doi.org/10.1038/nsmb.2928
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ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function
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