Two proposed mechanisms for how microRNAs (miRNAs) and their associated Argonaute proteins inhibit translation in mammals do not seem to operate in Drosophila melanogaster cells, suggesting that insights into important miRNA functions remain elusive. However, the interaction between Argonaute and the P-body factor GW182 may help in elucidating the biochemical basis of translational control by miRNAs.
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Richter, J. Think you know how miRNAs work? Think again.. Nat Struct Mol Biol 15, 334–336 (2008). https://doi.org/10.1038/nsmb0408-334
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DOI: https://doi.org/10.1038/nsmb0408-334