Abstract
Block copolypeptides of γ-benzyl L-glutamate (BLG) and ε-carbobenzoxy L-lysine (CBL) were synthesized by polymerization of the corresponding amino acid-N-carboxy anhydrides with initiation by n-butylamine. Optical rotatory dispersion data showed that the block copolypeptides of the type BLG—CBL—BLG were essentially helical in m-cresol at 20°C, despite the fact that in the same solvent conditions isolated CBL chains assume a completely randomly coiled conformation. Dielectric dispersion and viscosity data indicated that the shape of the triblock copolypsptide was rodlike. These results suggest that the central CBL block is forced to take up a rigid helical conformation by an interaction from the flanking BLG blocks, which tend to assume a stable helical conformation under the solvent conditions studied. The conformational induction by the BLG blocks extends over a distance as long as 60 CBL residues when each of the BLG blocks is 20 residues long.
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Nishioka, N., Teramoto, A. & Fujita, H. Conformation of Block Copolypeptides of γ-Benzyl L-GIutamate and ε-Carbobenzoxy L-Lysine in m-Cresol. Polym J 8, 121–128 (1976). https://doi.org/10.1295/polymj.8.121
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DOI: https://doi.org/10.1295/polymj.8.121