Abstract
1009 patients suffering from eczema or other skin disorders have received elective primary vaccination with the CVI-78 strain of vaccinia. The vaccine is attenuated by repeated passage through chick embryoes; its infectivity titer is 8.4 (TCD50/ml), and it is free of bacteria. It was administered by one of three routes (multiple pressure, subcutaneously or jet gun) with a minimal dose of TCID50 of 1000 and a maximal dose of TCID50 of 30,000. Local and systemic reactions and temperature elevations in these children were significantly less marked than those experienced with a standard strain of vaccinia in normal children. No virus dissemination or other complications occurred, except for two instances of mild erythema multiforme. Seroconversion was noted in all 387 patients tested to date. Multiple pressure revaccination with a standard strain one to six months later resulted in marked modification in the reaction to the standard strain; no systemic reactions developed. It would appear that CVI strain of vaccinia virus is effective for elective primary vaccination of children suffering from eczema for prevention of eczema vaccinatum. (APS)
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Kempe, C. 38 Attenuated Vaccinia in the Elective Primary Vaccination of Eczema Patients. Pediatr Res 1, 210 (1967). https://doi.org/10.1203/00006450-196705000-00045
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DOI: https://doi.org/10.1203/00006450-196705000-00045