Abstract
Drainage of the abdominal chyleduct was carried out for 1–18 days in 11 rats, a continuous i.v. drip preventing dehydration. Marked hypoalbuminemia (with values < 1.0 gm %) developed in all and cholesterol and total lipid values in sera remained within normal limits. At the same time electrophoretic patterns obtained on sera of these rats showed the appearance of proteins with the mobility of α2 globulins that were not obtained before. Marked decreases of γ globulins were also noted. In as much as these observations were made on animals without kidney disease, it would seem possible that the increase of α2 globulins observed regularly in the nephrotic syndrome do not reflect any etiological or pathogenic manifestation of the disease process. These observations also do not support the contention that the nephrotic hyperlipemia is due to hypoalbuminemia. Sera of 5 children with non nephrotic hypoalbuminemias also revealed normal cholesterol and total lipid values with increased α2 globulins. (APS)
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heymann, W., Ghentow, S. & Zitel, J. 44 Experimental Studies on Pathogenesis of Nephrotic Hyperlipemia and Dysproteinemia. Pediatr Res 1, 211 (1967). https://doi.org/10.1203/00006450-196705000-00051
Issue Date:
DOI: https://doi.org/10.1203/00006450-196705000-00051