Abstract
A 2-year-old boy was admitted to hospital with acute hemolytic anemia, acute renal failure and cerebral dysfunction 16 hours after ingesting 20-30g supersaturated solution of copper sulphate. He was drowsy, febrile and anuric. Serum copper was 201μg/dl, ceruloplasmin 40mg/dl. Peritoneal dialysis was started and antibiotic coverage was initiated.
57 hours after ingestion with no change in serum copper levels or clinical status, exchange transfusion was carried out and salt-poor albumin (2.5g/dl) was added to the dialysate. Serum copper following dialysis was 123μg/dl and his clinical status improved. Dialysate copper concentrations were measured:
Diuresis occurred on day 22. BUN and creatinine are normal 255 days following ingestion although copper (176μg/dl) and ceruloplasmin (42μg/dl) remain elevated.
These data suggest a beneficial role of exchange transfusion and peritoneal dialysis with albumin in the treatment of copper sulphate poisoning with acute renal failure.
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Cole, D., Lirenman, D. & Segal, S. PERITONEAL DIALYSIS IN ACUTE COPPER SULPHATE POISONING. Pediatr Res 11, 548 (1977). https://doi.org/10.1203/00006450-197704000-01071
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DOI: https://doi.org/10.1203/00006450-197704000-01071