Abstract
Immunofluorescent studies have provided indirect evidence of disordered secretin release from the jejunal mucosa S-cells in coeliac disease. We measured the plasma secretin response to duodenal acidification in 15 normal children, 6 with active coeliac disease, and 6 with treated coeliac disease. Citric acid (0.5M, 5ml/Kg) was infused into the duodenum prior to jejunal biopsy. Plasma secretin was measured by a specific and sensitive radioimmuno assay. In the normal group secretin from from 1.3 ± 0.7 pmol/l to 24.7 ± 3.5 pmol/l at 10 minutes, in the active coeliacs from 1.7 ± 0.9 pmol/1 to 6.3 ± 1.2 pmol/l and in treated coeliacs from 0.9 ± 0.6 pmol/l to 33.8 ± 6.9 pmol/l. The secretin response in active coeliac disease was significantly reduced (p 0.001) and may contribute to impaired pancreatic exocrine function.
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Johnston, D., Patel, H., Bloom, S. et al. Secretin release in Children with Coeliac Disease. Pediatr Res 12, 149 (1978). https://doi.org/10.1203/00006450-197802000-00018
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DOI: https://doi.org/10.1203/00006450-197802000-00018