Abstract
The increased incidence of PDA in premature infants, especially those with RDS, has been well documented. The occurrence of bronchopulmonary dysplasia (BPD) in infants with RDS and PDA has been used by some centers as indication for early medical or surgical closure of the PDA. An epidemiologic analysis of 11 variables in 257 infants with RDS treated in 1974-76 was performed to determine specific differences between 47 infants with a PDA and 210 with no PDA. BPD occurred in 11 (22.4%) infants with a PDA and 7 (3.3%) with no PDA (X2=19.59, p=<0.0001). The duration of artificial ventilation and hospitalization was also significantly greater for infants with a PDA. Events that occurred early in the clinical course and before the signs of the PDA developed were chosen for analyses in order to determine if the severity of the RDS was greater in those infant who later developed signs of a PDA. The oxygen requirements at 6 to 36 hours of age showed a significant difference in distribution of Fi02 values toward the higher ranges in the PDA infants. Mechanical ventilation was required in 30/44 (61.2%) of the PDA vs. 60/179 (28.6%) (X2=17.3, p=<0.0001) of the no PDA patients requiring respiratory therapy. The decision for the use of mechanical ventilation in all patients was reached at a mean of 2 days whereas the signs of PDA developed at a mean of 8.4 days. These data indicate the possibility of a common developmental defect that produces marked immaturity of the lune and delay in ductal closure.
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Peckham, G., Heskell, N. & Cortner, J. 375 EPIDEMIOLOGY OF PATENT DUCTUS ARTERIOSUS (PDA) IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 12 (Suppl 4), 426 (1978). https://doi.org/10.1203/00006450-197804001-00380
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DOI: https://doi.org/10.1203/00006450-197804001-00380