Abstract
5 boys with congenital NDI have been treated with indomethacin 3mg/kg/24 hours for 12-33 months. All experienced a 20-40% reduction of urine output and three reported increased well-being. A 10% mannitol loading test was performed before and after treatment for 1 week with the following results:-
After treatment for up to 33 months plasma creatinine and serum electrolytes remained normal. One boy was found to have symmetrically distributed non-calcified cerebral opacities unlike those of tuberose sclerosis but they were not found in two others. We conclude that the concentrating defect in NDI is not mediated by increased prostaglandin production and that indomethacin does not exert its beneficial effect by altering collecting duct permeability to water.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Winterborn, M., Rayner, P. & Shah, K. NEPHROCENIC DIABETES INSIPIDUS (NDI) TREATED WITH INDOMETHACIN. Pediatr Res 14, 1008 (1980). https://doi.org/10.1203/00006450-198008000-00210
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00210