Abstract
Ca, Mg, 25(OH)D, 24,25- and 1,25(OH)2D and PTH (estimated with antibodies which mainly recognize intact PTH-(1-84)) were measured in the serum of normal non-pregnant adults (C) as well as at delivery. Maternal venous (M) and umbilical venous (UV) and arterial (UA) blood was obtained from normal mothers and neonates at term (N=12). Mean levels (±SE) amounted to:
24,25(OH)2D was lower and 1,25(OH)2D higher at the end of pregnancy than in non-pregnant controls, presumably in response to raised fetal demands of calcium. Vitamin D-metabolites were lower in cord than in maternal blood possibly because of a diffusion barrier accross the placenta and/or different affinities of binding proteins. However, higher levels of 1,25(OH)2D in UA than in UV suggest that the fetus also participates in the synthesis of 1,25(OH)2D. Finally serum levels of calcium were higher in UV than in M and fetal PTH was undetectable or low.
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Wieland, P., Trechsel, U., Vetter, K. et al. Perinatal calcium homeostasis: Maternal and cord serum concentrations of Ca, Mg, vit. D-metabolites and parathyroid hormone (PTH): 48. Pediatr Res 14, 173 (1980). https://doi.org/10.1203/00006450-198002000-00075
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DOI: https://doi.org/10.1203/00006450-198002000-00075