Abstract
The effect of bacterial infection on PMN CX has not been studied in detail. Whether infection causes impairment or enhancement is controversial. The response during infection, to chemotactic factors (CF) generated by the pathogen is unknown. 14 patients (mean age 4.5 yrs) and 14 age matched controls were studied. 4 had septicemia; 1 meningitis; 5 UTI, 6 Enteritis and 1 otitis media. The organisms isolated (Pneumococcus, Shigella, Pseudomonas, E. coli, Klebsiella and Salmonella) were grown in broth. CF for each organism (OCF) was obtained. 12 patients were studied before and 2 during antibiotic therapy. CX was performed utilizing Boyden's technique. PMNS placed on 3 μ micropore filter were tested against OCF, endotoxin activated serum (EAS) and an standard E. coli CF (ECF) to determine chemotactic index (CI) and against Hank's solution random migration (RM). The mean (± 1SD) CI and RM are presented (table). CI obtained with the 3 CFs were decreased and RM unchanged compared with controls. These findings suggest that the invading organism contributes to the host's vulunerability and may impair recovery by decreasing CX.
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Khan, A., Varghese, M., Kumar, K. et al. 1036 THE EFFECT(s) OF FACTOR(s) GENERATED BY INVADING PATHOGENS ON CHEMOTAXIS (CX) OF HOST NEUTROPHILS (PMNS). Pediatr Res 15 (Suppl 4), 615 (1981). https://doi.org/10.1203/00006450-198104001-01062
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DOI: https://doi.org/10.1203/00006450-198104001-01062