Abstract
To explore abnormalities of carbohydrate metabolism in obesity, we studied Ra and Cl in 11 obese male and female adolescents under basal conditions. Eight of the same patients were also studied in a crossover fashion on a diet containing 1.5 gm meat protein/kg IBW/d and 1.0 gm glucose/kg IBW/d (P+G) or an isocaloric, isonitrogenous, carbohydrate-free diet (P+F). Glucose (G) kinetics were studied using a primed constant infusion of U-13C-glucose after an overnight fast.
Basal Ra was 2,63 ± .50 mg/kg IBW, was unaffected by short term weight reduction and was readily suppressed by the infusion of 1 mg unlabelled glucose/kg IBW. In the basal state Ra did not correlate with insulin (I) or free fatty acid (FFA) levels. During hypocaloric dietary therapy Ra fell to 77% of baseline; the decrease was similar for both diets. Cl and % CO2 from G were significantly lower on P+F than on P+G. Under all conditions, Cl did not correlate with FFA or I. Percent CO2 from G was inversely correlated with FFA only with P+G, but did not correlate with I on either diet.
Caloric intake rather than energy source appears to be the primary determinant of Ra. Contrary to previous hypotheses, our kinetic data suggest that Ra, Cl, and Ox are generally unrelated to levels of I and FFA during hypocaloric dietary therapy.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dietz, W., Wolfe, R. & Grand, R. 1116 GLUCOSE TURNOVER IN ADOLESCENTS: EFFECT OF OBESITY AND DIET ON RATES OF GLUCOSE PRODUCTION (Ra), CLEARANCE (C1) AND OXIDATION (OX). Pediatr Res 15 (Suppl 4), 628 (1981). https://doi.org/10.1203/00006450-198104001-01142
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-01142