Abstract
Thyroid hormone is thought to augment renal cellular and mitochondrial metabolism and has been shown to improve the enzymatic activity of tubular cell following mercuric chloride injury. To determine the effect of this hormone on the recovery from toxic acute renal failure, rats were injected, subcutaneously, with K-dichromate (15 mg/kg), a known tubular toxin. At the peak of the renal injury, 24 hours after injection, the animals were given, intraperitoneally, either thyroxin (T4) 4 μg/100g BW (twice physiologic dose) or 0.5 cc of normal saline. Inulin clearance (Cin) was measured 24 hours later.
As expected, the 11 animals given normal saline had a significant fall of Cin to 422.2 ± 27.2 μl/min/100g BW (P < 0.001 compared to control values, 1037.4 ± 48.6). In contrast, the 11 rats treated with T4 had significantly improved recovery of Cin to 678.2 ± 55.7 (P < 0.001). The same dose of T4 given to shaminjected control animals failed to produce a similar increase in Cin (1023.3 ± 33.1, P = NS).
These data suggest that treatment with thyroxin will significantly ameliorate the fall in Cin following a toxic renal insult and that this effect is not due to a non-specific enhancement of glomerular filtration rate.
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Siegel, N., Reilly, H. & Hendier, F. 1538 AMELIORATION OF TOXIC ACUTE RENAL FAILURE BY TREATMENT WITH THYROXIN. Pediatr Res 15 (Suppl 4), 699 (1981). https://doi.org/10.1203/00006450-198104001-01561
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DOI: https://doi.org/10.1203/00006450-198104001-01561