Abstract
In 5 girls with PP who had been treated with CPA (95-133 mg/m2 × d) for years, the spontaneous secretion (4-hourly) and the pituitary reserves of LH,FSH,TSH,HGH, and ACTH (as measured by cortisol (F) and dehydroepiandrosterone sulfate (DS)) were determined before and 3 months (m) after discontinuation of the drug. All hormones were measured by RIAs previously described. For PRL the Serono Kit was used. - During CPA therapy (tx) the most consistent abnormalities found were elevated PRL levels after stimulation (200/ug TRH and insulin-induced hypoglycaemia (IIH)) and low F concentrations with subnormal responses to IIH. Basal and stimulated (25/ug LH-RH, 200/ug TRH) concentrations of LH,FSH, TSH were variable (low, normal, or normal to elevated). DS concentrations were unmeasurable or low (<25-120/ug/ml). Discontinuation of CPA resulted in a rapid normalization of basal F and PRL. After 3 m off tx the F responses to IIH were normal except in 1 girl (ΔF 59-176 ng/ml). Δ PRL had normalized to 26.2-39.7 ng/ml (during CPA 36.9-95.6 ng/ml). FSH remained unchanged and LH increased in 2 girls. HGH remained subnormal in 1 patient. - We conclude that PRL and F levels are rapidly normalized after discontinuation of CPA, while other parameters are not consistently changed.
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Grueters, A., Schwartz, D., Beyer, P. et al. Changes of pituitary and adrenal functions after discontinuation of cyproterone acetate (CPA) therapy in girls with precocious puberty (PP). Pediatr Res 15, 77 (1981). https://doi.org/10.1203/00006450-198101000-00035
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DOI: https://doi.org/10.1203/00006450-198101000-00035