Abstract
Serial studies of PMN motility & adherence were performed in 25 children (age 2 mos-14 yrs) with “severe” PCM. Initial assessments demonstrated diminished PMN chemotaxis in 17/20 cases; x migration scores were 64±16% of control (C) to bacterial chemotactic factor (BCF), & 65±21% to zymosan activated sera (ZAS) (p <.001). Chemotaxis to ZAS was further diminished when PMNs were suspended in “severe” autologous plasma (54±14% of C). In subsequent studies in 14 nutritionally “restored”π pts (x wt/ht=27th %ile & x serum pre-albumin=25 mg/dl), chemotactic responses were 87±14% (BCF) & 94±14% (ZAS) of C while decreased scores were constant in pts not achieving nutritional recovery. Abnormalities of PMN adherence to albumin-coated glass substrates were concurrently identified; baseline PMN adherence values were significantly (p<.001) increased in “severe” PCM (49±8%) compared to normal C values (21±11%) or respective “nutritionally restored” values (20±12%). Also, x chemotactic factor (CF) induced adherence increments (above baseline) as seen with C PMNs (BCF, +31±14%, f-Met-Leu-Phe, +34±14%) were not observed in “severe” PCM (BCF, + 0.84±14%; f-Met-Leu-Phe, −0.2±20%) (p<.001). In contrast, normal CF-adherence increments were observed in respective PCM pts following nutritional recovery (BCF, +25±9%; f-Met-Leu-Phe, +23±11%)., impaired chemotaxis in PCM is related to intrinsic abnormalities of PMN adherence or CF effects on adhesive function, & the presence of a cell directed inhibitor of motility in PCM plasma.
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Anderson, D., Krishna, G. & Nichols, B. 508 IMPAIRED CHEMOTAXIS RELATED TO ABNORMALITIES OF PMN LEUKOCYTE ADHERENCE IN PROTEIN-CALORIE MALNUTRITION (PCM). Pediatr Res 15 (Suppl 4), 525 (1981). https://doi.org/10.1203/00006450-198104001-00521
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DOI: https://doi.org/10.1203/00006450-198104001-00521