Abstract
CO decreases with increasing mean airway pressure (MAP) during PPV. Since MAP can be varied by altering inspiratory pressure (IP), expiratory pressure (EP), or the I/E time ratio, and since E during PPV may be a time for recovery, differing patterns of pressure delivery at the same MAP may produce differing effects on CO. CO (microspheres) and left ventricular end diastolic dimension (LVED by echo) as an estimate of LV volume were measured in 10 paralyzed newborn dogs during PPV. Baseline (B) ventilation was produced by using the least IP and EP to maintain normocarbia (rate 50, I/E of 1/3). Each animal had 4 experimental ventilatory variations: 1 at B, and 3 at a MAP 3X B produced by independently varying IP, I/E or EP.
The similar reductions in LVED, CO, and stroke volume seen with a 3-fold increase in MAP are due primarily to a decrease in pre-load. We conclude that these reductions are independent of the pattern of pressure delivery.
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Reller, M., Donovan, E. & Kotagal, U. THE EFFECT OF VARYING PATTERNS OF PRESSURE DELIVERY DURING POSITIVE PRESSURE VENTILATION(PPV)ON CARDIAC OUTPUT (CO). Pediatr Res 18 (Suppl 4), 128 (1984). https://doi.org/10.1203/00006450-198404001-00213
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DOI: https://doi.org/10.1203/00006450-198404001-00213