Abstract
During S, brain acidosis often associated to blood alkalosis (1) lead to a rise in blood-brain [H+] gradient (G [H+]). According to the pH partition hypothesis PB should be released from brain tissue. To test this hypothesis 11 piglets less than 10 days are studied (mean weight ± 1 SD : 1.7 ± 0.6 kg) 6 to 12 hours after an IP dose of 10 mg/kg of PB. S are induced by pentylen tetrazol (P-100 mg/kg, n=4) or bicuculline (B-0.6 ± 1.2 mg/kg, n=7) in sponta neously breathing anesthetized animals (urethan 12.5 % sol, 15ml/kg), PaO2, PaCO2, pHa, brain tissue pH (Roche electrode), blood and brain PB concentrations are measured. S lasted for 3 to 17 min. Mean changes are as follows :
During S, the brain/arterial PB ratio (b/a) rises from 0.83±0.18 to 1.03 ± 0.30 (m + 1 SD). It is > 1 in one case before S (1.08) and in 7 cases during S (X2 = 7.0, p < 0.01) . This suggest an unexpected PB intrusion into the brain during S which could be related to an opening of the blood brain barrier (BBB) as suggested by 1) the correlation between b/a and Δ G [H+] (r=0.67, p < 0.05) and 2) the trend towards a correlation between brain PB and brain [H+] changes during S (r=0.61, ns). During S, higher is brain acidosis higher might be the BBB opening and the PB shift into the brain. 1. P. MONIN et al, Pediatr. Res., 1979, 13 : 527, *ns, **p < 0.01.
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Monin, P., Clozel, M., Vert, P. et al. BRAIN PHENOBARBITAL (PB) CHANGES DURING SEIZURES (S) IN PIGLETS. Pediatr Res 18 (Suppl 4), 156 (1984). https://doi.org/10.1203/00006450-198404001-00378
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DOI: https://doi.org/10.1203/00006450-198404001-00378